Therapeutic Drug Monitoring

With our complete solutions in therapeutic drug monitoring (TDM) covering assays as well as calibrators and controls, we help you in getting reliable results efficiently. We offer solutions for LC-MS/MS and HPLC, all of them are validated and comply with relevant regulatory rules, thereby ensuring confident results in your laboratory. 

  • CE-IVD validated methods 
  • Series A with 200 drugs with one column and sample preparation
  • One Minute assay for immunosuppressants 


  More information on MassTox® TDM Series A

Master Column

One analytical column for all Parameter Sets. No column switching required.

Order No. Product
92110 MassTox® TDM MasterColumn® A

Basic Kits

Contain all components required for a complete sample preparation and all necessary mobile phases.

Order No. Product
92111/200 Basic Kit A for 200 Tests
92111/1000 Basic Kit A for 1000 Tests
92111/1000/F Basic Kit A for 1000 Tests, automated

Parameter Sets in Serum/Plasma

Contain all relevant calibrators, quality controls and internal standards.

Order No. Product
92923 Antiarrhythmic Drugs
92913/XT Antidepressants 1/EXTENDED
92915/XT Antidepressants 2/Psychostimulants/EXTENDED
92921/XT Antiepileptic Drugs All-in-One Method
92924 Anti-HIV Drugs
92922/XT Antimycotic Drugs/EXTENDED
92917 Benzodiazepines 1
91918 Benzodiazepines 2
92916 Mycophenolic Acid
92912/XT Neuroleptics 1/EXTENDED
92914/XT2 Neuroleptics 2/EXTENDED 2
92919 Tricyclic Antidepressants TCA 1
92920 Tricyclic Antidepressants TCA 2

Parameter Overview

Antiarrhythmic Drugs (92923)

Acebutolol, Ajmaline, Amiodarone, Desethylamiodarone, Aprindine, Atenolol, Bisoprolol, Diltiazem, Disopyramide, Dronedarone, Debutyldronedarone, Flecainide, Flunarizine, Gallopamil, Lidocaine, Metoprolol, Mexiletine, Propafenone, Propranolol, Quinidine, Hydroquinidine, Sotalol, Tocainide, Verapamil, Norverapamil

Antidepressants 1/EXTENDED (92913/XT)

Citalopram, N-Desmethylcitalopram, Duloxetine, Fluoxetine, Desmethylfluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylmirtazapine, Paroxetine, Sertraline, N-Desmethylsertraline, Venlafaxine, O-Desmethylvenlafaxine

Antidepressants 2/ Psychostimulants/EXTENDED (92915/XT)

Atomoxetine, Bupropion, Erythro-Dihydrobupropion, Threo-Dihydrobupropion, Hydroxybupropion, Clomethiazole, Dosulepin, N-Desmethyldosulepin, Methylphenidate, Mianserin, Milnacipran, Moclobemide, Opipramol, Reboxetine, Ritalinic acid, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine

Antiepileptic Drugs All-in-One Method (92921/XT)

Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, 10-OH-Carbamazepine, 10,11-Dihydroxycarbamazepine, Desmethylmesuximide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Oxcarbazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Tiagabine, Theophylline, Topiramate, Valproic acid, Vigabatrin, Zonisamide

Anti-HIV Drugs (92924)

Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Saquinavir

Antimycotic Drugs/EXTENDED (92922/XT)

Amphotericin B*, Anidulafungin, Caspofungin, Fluconazole, 5-Flucytosine, Isavuconazole, Itraconazole, Hydroxyitraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole

Benzodiazepines 1 (92917)

Chlordiazepoxide, Clobazam, Norclobazam, Demoxepam, Diazepam, Nordiazepam, Medazepam, Midazolam, 1-OH-Midazolam, Oxazepam, Prazepam, Temazepam, Tetrazepam

Benzodiazepines 2 (92918)

Alprazolam, Bromazepam, Clonazepam, Flunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Nitrazepam, Triazolam

Mycophenolic Acid (92916)

Mycophenolic acid, Mycophenolic acid glucuronide

Neuroleptics 1/EXTENDED (92912/XT)

Aripiprazole, Dehydroaripiprazole, Clozapine, N-Desmethylclozapine, Haloperidol, Olanzapine, N-Desmethylolanzapine, Quetiapine, Norquetiapine, Risperidone, 9-OH-Risperidone

Neuroleptics 2/EXTENDED 2 (92914/XT2)

Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol

Tricyclic Antidepressants TCA1 (92919)

Amitriptyline, Desipramine, Doxepin, Nordoxepin, Imipramine, Nortriptyline

Tricyclic Antidepressants TCA2 (92920)

Clomipramine, Norclomipramine, Maprotiline, Normaprotiline, Protriptyline, Trimipramine, Nortrimipramine

* For Amphotericin B only qualitative information can be obtained, but data are not CE-IVD compliant.


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MassTox® Immunosuppressants in Whole Blood

Order No. Assay Parameters Number of tests
Immunosuppressants Cyclosporin A
Immunosuppressants – ONEMinute Test 400
93900/1200/F Immunosuppressants – ONEMinute Test for automated sample preparation 1200

Immunosuppressants Assays Now Licensed in Canada:
Chromsystems has obtained a class III license for the MassTox® Immunosuppressant kits in whole blood, including the One Minute Test. This assay allows the determination of the four immunosuppressants with a run time of only 1-2 minutes per sample.

The manual sample prep for the One Minute Test is reduced to a simple and effective protein precipitation. The concentration of the analytes and the elimination of other interfering substances is performed online using a trap column, which massively minimises matrix effects. The isotopically labelled internal standards compensate entirely for remaining ion suppression. 6PLUS1® multilevel calibrators and MassCheck® controls ensure results of highest precision. Automated assays are also available for laboratories with a maximum of sample throughput.

Overview TDM Assays by HPLC

Order No. Assay Parameters Automation
61000 Antibiotics in Serum/Plasma Ampicillin, cefepime, ceftazidime, linezolid, meropenem, piperacillin, sulbactam, tazobactam  
25000 Amiodarone and Desmethylamiodarone in Serum/Plasma Amiodarone, desethylamiodarone  

Antiepileptic Drugs in Serum/Plasma
Fast Elution
10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone Gilson Flexus®/ASPEC®

Antiepileptic Drugs in Serum/Plasma
High Resolution
10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, lamotrigine, oxcarbamazepine (Trileptal®), phenobarbital, phenytoin, primidone, sultiame, zonisamide Gilson Flexus®/ASPEC®
49000 Benzodiazepines and Tricyclic Antidepressants in Serum/Plasma Alprazolam, amitriptyline, bromazepam, chlordiazepoxide, clobazam, clomipramine, clonazepam, clozapine, desipramine, diazepam, doxepin, flunitrazepam, imipramine, maprotiline, nitrazepam, norclobazam, norclomipramine, norclozapine, nordiazepam, nordoxepin, nortriptyline, oxazepam, trimipramine Gilson Flexus®/ASPEC®
27037 Itraconazole, Posaconazole and Voriconazole in Serum/Plasma Itraconazole, hydroxyitraconazole, posaconazole, voriconazole  
24000 Levetiracetam (Keppra®) in Serum/Plasma Levetiracetam (Keppra®)  
46000 Mycophenolic Acid in Plasma/Serum Mycophenolic acid  
26000 Olanzapine and Desmethylolanzapine in Serum/Plasma Olanzapine, desmethylolanzapine, quetiapine  
21000 Rufinamide, Felbamate and Lacosamide in Serum/Plasma Eslicarbazepine, felbamate, lacosamide, N-desmethylmesuximide, rufinamide