

Therapeutic Drug Monitoring
With our complete solutions in therapeutic drug monitoring (TDM) covering assays as well as calibrators and controls, we help you in getting reliable results efficiently. We offer solutions for LC-MS/MS and HPLC, all of them are validated and comply with relevant regulatory rules, thereby ensuring confident results in your laboratory.
- CE-IVD validated methods
- Series A with 200 drugs with one column and sample preparation
- One Minute assay for immunosuppressants
TDM with LC-MS/MS or HPLC
Find more information on MassTox® TDM Series A here
Master Column
One analytical column for all Parameter Sets. No column switching required.
Order No. | Product |
92110 | MassTox® TDM MasterColumn® A |
Basic Kits
Contain all components required for a complete sample preparation and all necessary mobile phases.
Order No. | Product |
92111/200 | Basic Kit A for 200 Tests |
92111/1000 | Basic Kit A for 1000 Tests |
92111/1000/F | Basic Kit A for 1000 Tests, automated |
Parameter Sets in Serum/Plasma
Contain all relevant calibrators, quality controls and internal standards.
Order No. | Product |
92923 | Antiarrhythmic Drugs |
92913/XT | Antidepressants 1/EXTENDED |
92915/XT | Antidepressants 2/Psychostimulants/EXTENDED |
92921/XT | Antiepileptic Drugs All-in-One Method |
92924 | Anti-HIV Drugs |
92922/XT | Antimycotic Drugs/EXTENDED |
92917 | Benzodiazepines 1 |
91918 | Benzodiazepines 2 |
92916 | Mycophenolic Acid |
92912/XT | Neuroleptics 1/EXTENDED |
92914/XT2 | Neuroleptics 2/EXTENDED 2 |
92919 | Tricyclic Antidepressants TCA 1 |
92920 | Tricyclic Antidepressants TCA 2 |
Parameter Overview
Download Brochure


MassTox® Immunosuppressants in Whole Blood
Order No. | Assay | Parameters | Number of tests |
93000 93000/1200 |
Immunosuppressants | Cyclosporin A Everolimus Sirolimus Tacrolimus |
400 1200 |
93900/400 93900/1200 |
Immunosuppressants – ONEMinute Test | 400 1200 |
|
93900/1200/DWP | Immunosuppressants – ONEMinute Test for automated sample preparation | 1200 |
Immunosuppressants Assays Now Licensed in Canada:
Chromsystems has obtained a class III license for the MassTox® Immunosuppressant kits in whole blood, including the One Minute Test. This assay allows the determination of the four immunosuppressants with a run time of only 1-2 minutes per sample.
The manual sample prep for the One Minute Test is reduced to a simple and effective protein precipitation. The concentration of the analytes and the elimination of other interfering substances is performed online using a trap column, which massively minimises matrix effects. The isotopically labelled internal standards compensate entirely for remaining ion suppression. 6PLUS1® multilevel calibrators and MassCheck® controls ensure results of highest precision. Automated assays are also available for laboratories with a maximum of sample throughput.
Overview TDM Assays by HPLC
Order No. | Assay | Parameters | Automation |
61000 | Antibiotics in Serum/Plasma | Ampicillin, cefepime, ceftazidime, linezolid, meropenem, piperacillin, sulbactam, tazobactam | |
25000 | Amiodarone and Desmethylamiodarone in Serum/Plasma | Amiodarone, desethylamiodarone | |
22000/F |
Antiepileptic Drugs in Serum/Plasma Fast Elution |
10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone | Gilson Flexus®/ASPEC® |
22000/HR |
Antiepileptic Drugs in Serum/Plasma High Resolution |
10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, lamotrigine, oxcarbamazepine (Trileptal®), phenobarbital, phenytoin, primidone, sultiame, zonisamide | Gilson Flexus®/ASPEC® |
49000 | Benzodiazepines and Tricyclic Antidepressants in Serum/Plasma | Alprazolam, amitriptyline, bromazepam, chlordiazepoxide, clobazam, clomipramine, clonazepam, clozapine, desipramine, diazepam, doxepin, flunitrazepam, imipramine, maprotiline, nitrazepam, norclobazam, norclomipramine, norclozapine, nordiazepam, nordoxepin, nortriptyline, oxazepam, trimipramine | Gilson Flexus®/ASPEC® |
27037 | Itraconazole, Posaconazole and Voriconazole in Serum/Plasma | Itraconazole, hydroxyitraconazole, posaconazole, voriconazole | |
24000 | Levetiracetam (Keppra®) in Serum/Plasma | Levetiracetam (Keppra®) | |
46000 | Mycophenolic Acid in Plasma/Serum | Mycophenolic acid | |
26000 | Olanzapine and Desmethylolanzapine in Serum/Plasma | Olanzapine, desmethylolanzapine, quetiapine | |
21000 | Rufinamide, Felbamate and Lacosamide in Serum/Plasma | Eslicarbazepine, felbamate, lacosamide, N-desmethylmesuximide, rufinamide |