Therapeutic Drug Monitoring

We offer complete solutions in therapeutic drug monitoring (TDM) covering assays as well as calibrators and controls. All of our LC-MS/MS and HPLC assays are validated and comply with relevant regulatory rules, thereby ensuring confident results in your laboratory.

CE-IVD validated methods
Series A with 200 drugs with one column and sample preparation
OneMinute Test for immunosuppressants
Robotic solution for more than 100 drugs

TDM with LC-MS/MS or HPLC

More information on MassTox® TDM Series A

Master Column

One analytical column for all Parameter Sets. No column switching required.

Order No.	Product
92110	MassTox® TDM MasterColumn® A

Basic Kits

Contain all components required for a complete sample preparation and all necessary mobile phases.

Order No.	Product
92111/200	Basic Kit A for 200 Tests
92111/1000	Basic Kit A for 1000 Tests
92111/1000/F	Basic Kit A for 1000 Tests, automated

Parameter Sets in Serum/Plasma

Contain all relevant calibrators, quality controls and internal standards.

Order No.	Product
92923	Antiarrhythmic Drugs
92913/XT	Antidepressants 1/EXTENDED
92915/XT	Antidepressants 2/Psychostimulants/EXTENDED
92921/XT	Antiepileptic Drugs All-in-One Method
92924	Anti-HIV Drugs
92922/XT	Antimycotic Drugs/EXTENDED
92917	Benzodiazepines 1
91918	Benzodiazepines 2
92916	Mycophenolic Acid
92912/XT	Neuroleptics 1/EXTENDED
92914/XT2	Neuroleptics 2/EXTENDED 2
92919	Tricyclic Antidepressants TCA 1
92920	Tricyclic Antidepressants TCA 2

Parameter Overview

Antiarrhythmic Drugs (92923)

Acebutolol, Ajmaline, Amiodarone, Desethylamiodarone, Aprindine, Atenolol, Bisoprolol, Diltiazem, Disopyramide, Dronedarone, Debutyldronedarone, Flecainide, Flunarizine, Gallopamil, Lidocaine, Metoprolol, Mexiletine, Propafenone, Propranolol, Quinidine, Hydroquinidine, Sotalol, Tocainide, Verapamil, Norverapamil

Antidepressants 1/EXTENDED (92913/XT)

Citalopram, N-Desmethylcitalopram, Duloxetine, Fluoxetine, Desmethylfluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylmirtazapine, Paroxetine, Sertraline, N-Desmethylsertraline, Venlafaxine, O-Desmethylvenlafaxine

Antidepressants 2/ Psychostimulants/EXTENDED (92915/XT)

Atomoxetine, Bupropion, Erythro-Dihydrobupropion, Threo-Dihydrobupropion, Hydroxybupropion, Clomethiazole, Dosulepin, N-Desmethyldosulepin, Methylphenidate, Mianserin, Milnacipran, Moclobemide, Opipramol, Reboxetine, Ritalinic acid, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine

Antiepileptic Drugs All-in-One Method (92921/XT)

Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, 10-OH-Carbamazepine, 10,11-Dihydroxycarbamazepine, N-Desmethylmesuximide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Oxcarbazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic acid, Vigabatrin, Zonisamide

Anti-HIV Drugs (92924)

Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Saquinavir

Antimycotic Drugs/EXTENDED (92922/XT)

Anidulafungin, Caspofungin, Fluconazole, 5-Flucytosine, Isavuconazole, Itraconazole, Hydroxyitraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole

Benzodiazepines 1 (92917)

Chlordiazepoxide, Clobazam, Norclobazam, Demoxepam, Diazepam, Nordiazepam, Medazepam, Midazolam, 1-OH-Midazolam, Oxazepam, Prazepam, Temazepam, Tetrazepam

Benzodiazepines 2 (92918)

Alprazolam, Bromazepam, Clonazepam, Flunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Nitrazepam, Triazolam

Mycophenolic Acid (92916)

Mycophenolic acid, Mycophenolic acid glucuronide

Neuroleptics 1/EXTENDED (92912/XT)

Aripiprazole, Dehydroaripiprazole, Clozapine, N-Desmethylclozapine, Haloperidol, Olanzapine, N-Desmethylolanzapine, Quetiapine, Norquetiapine, Risperidone, 9-OH-Risperidone

Neuroleptics 2/EXTENDED 2 (92914/XT2)

Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol

Tricyclic Antidepressants TCA1 (92919)

Amitriptyline, Desipramine, Doxepin, Nordoxepin, Imipramine, Nortriptyline

Tricyclic Antidepressants TCA2 (92920)

Clomipramine, Norclomipramine, Maprotiline, Normaprotiline, Protriptyline, Trimipramine, Nortrimipramine

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MassTox® Immunosuppressants in Whole Blood

Order No.	Assay	Parameters	Number of tests
93000 93000/1200	Immunosuppressants	Cyclosporin A Everolimus Sirolimus Tacrolimus	400 1200
93900/400 93900/1200	Immunosuppressants – ONEMinute Test		400 1200
93900/1200/DWP	Immunosuppressants – ONEMinute Test for automated sample preparation		1200

Immunosuppressants Assays Now Licensed in Canada:
Chromsystems has obtained a class III license for the MassTox® Immunosuppressant kits in whole blood, including the One Minute Test. This assay allows the determination of the four immunosuppressants with a run time of only 1-2 minutes per sample.

The manual sample prep for the One Minute Test is reduced to a simple and effective protein precipitation. The concentration of the analytes and the elimination of other interfering substances is performed online using a trap column, which massively minimises matrix effects. The isotopically labelled internal standards compensate entirely for remaining ion suppression. 6PLUS1® multilevel calibrators and MassCheck® controls ensure results of highest precision. Automated assays are also available for laboratories with a maximum of sample throughput.

Overview TDM Assays by HPLC

Order No.	Assay	Parameters	Automation
61000	Antibiotics in Serum/Plasma	Ampicillin, cefepime, ceftazidime, linezolid, meropenem, piperacillin, sulbactam, tazobactam
25000	Amiodarone and Desmethylamiodarone in Serum/Plasma	Amiodarone, desethylamiodarone
22000/F	Antiepileptic Drugs in Serum/Plasma Fast Elution	10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, phenobarbital, phenytoin, primidone	Gilson Flexus®/ASPEC®
22000/HR	Antiepileptic Drugs in Serum/Plasma High Resolution	10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, lamotrigine, oxcarbamazepine (Trileptal®), phenobarbital, phenytoin, primidone, sultiame, zonisamide	Gilson Flexus®/ASPEC®
49000	Benzodiazepines and Tricyclic Antidepressants in Serum/Plasma	Alprazolam, amitriptyline, bromazepam, chlordiazepoxide, clobazam, clomipramine, clonazepam, clozapine, desipramine, diazepam, doxepin, flunitrazepam, imipramine, maprotiline, nitrazepam, norclobazam, norclomipramine, norclozapine, nordiazepam, nordoxepin, nortriptyline, oxazepam, trimipramine	Gilson Flexus®/ASPEC®
27037	Itraconazole, Posaconazole and Voriconazole in Serum/Plasma	Itraconazole, hydroxyitraconazole, posaconazole, voriconazole
24000	Levetiracetam (Keppra®) in Serum/Plasma	Levetiracetam (Keppra®)
46000	Mycophenolic Acid in Plasma/Serum	Mycophenolic acid
26000	Olanzapine and Desmethylolanzapine in Serum/Plasma	Olanzapine, desmethylolanzapine, quetiapine
21000	Rufinamide, Felbamate and Lacosamide in Serum/Plasma	Eslicarbazepine, felbamate, lacosamide, N-desmethylmesuximide, rufinamide