Biogenic Amines

Biogenic amines and their metabolites are important for the diagnosis of a number of diseases such as phaeochromocytoma or other tumours of the nervous system. Reliable results in routine diagnostics are therefore of clinical significance. We offer a range of reliable CE-IVD solutions for HPLC and LC-MS/MS as well as for urine and plasma as matrices. For our LC-MS/MS assays, you may also choose from two different configurations – with 96 SPE well plates or sample clean up columns.

  • Assays for HPLC and LC-MS/MS 
  • CE-IVD validated solutions 
  • For urine and plasma

Assay Overview 

Biogenic Amines in Urine

Order No. Chromatographic Platform Features
80000 MassChrom® Biogenic Amines/Metabolites in Urine – Chromatographic Platform consists of Mobile Phases, Rinsing Solution and Analytical Column
Order No. Sample Prep Sets Parameters
80600/96
80600/480
Catecholamines, free Metanephrines, Serotonin – with 96 SPE Well Plate Adrenaline
Noradrenaline
Dopamine
Free Metanephrine
Free Normetanephrine
Free 3-Methoxytyramine
Serotonin
80600/C Catecholamines, free Metanephrines, Serotonin – with Sample Clean Up Columns
80700/96 Total Metanephrines (free + conjugated) – with 96 SPE Well Plate Total Metanephrines
Total Normetanephrines
Total 3-Methoxytyramine
80700/C Total Metanephrines (free + conjugated) – with Sample Clean Up Columns
80800/96
80800/480
VMA, HVA, 5-HIAA – with Collection Plates Vanillylmandelic acid (VMA)
Homovanillic acid (HVA)
5-Hydroxyindoleacetic acid (5-HIAA)
80800 VMA, HVA, 5-HIAA – with Autosampler Vials

Biogenic Amines in Plasma

Order No. Assay Parameters
81000 MassChrom® Free Metanephrines in Plasma – with 96 SPE Well Plate Free Metanephrine
Free Normetanephrine
Free 3-Methoxytyramine
81000/C MassChrom® Free Metanephrines in Plasma – with Sample Clean Up Columns

The LC-MS/MS assays are aimed at the determination of biogenic amines, including solutions for plasma and urine matrices. They are available in 96 SPE well plate format or alternatively with sample clean up columns. Laboratories with higher sample throughput can also rely on our automated solutions. Isotope-labelled internal standards for each analyte and 6PLUS1® Multilevel Calibrator Sets as well as MassCheck® controls ensure a reliable and safe determination of the analytes.

  • Fast and efficient sample preparation procedures
  • Stable Internal Standards for every analyte
  • Fully automated workflows available

HPLC Assays for Urine

Order No. Substance/Group Parameters Automation
6000 Catecholamines Adrenaline/Epinephrine
Noradrenaline/Norepinephrine
Dopamine
Gilson Flexus®/ASPEC®
2020 Metanephrines Metanephrines
Normetanephrines
3-Methoxytyramine
Gilson Flexus®/ASPEC®
6000/Combi
2020/Combi
Catecholamines and Metanephrines Adrenaline/Epinephrine
Noradrenaline/Norepinephrine
Dopamine
Metanephrines
Normetanephrines
3-Methoxytyramine
 
4000 Serotonin Serotonin  
1000/B VMA, HVA, 5-HIAA Vanillylmandelic acid (VMA)
Homovanillic acid (HVA)
5-Hydroxyindoleacetic acid (5-HIAA)
Gilson Flexus®/ASPEC®
51000 5-HIAA 5-Hydroxyindoleacetic acid (5-HIAA)  

HPLC Assays for Plasma, Serum and Whole Blood

Order No. Substance/Group Parameters Matrix
5000 Catecholamines Adrenaline/Epinephrine
Noradrenaline/Norepinephrine
Dopamine
Plasma
3030 Serotonin Serotonin Serum
Plasma
Whole Blood

The reliable and proven HPLC assays allow the determination of biogenic amines, covering solutions for plasma, whole blood and urine matrices.

  • CE-IVD validated assays
  • Robust assays
  • Combined assays for catecholamines and metanephrines

 


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