Drugs of Abuse
The powerful assay enables the simultaneous quantitative determination of 108 drugs and metabolites in a single run, offering a broad spectrum for urine diagnostics. All analytes are validated in compliance with IVDR and meet the relevant regulatory requirements.
- 108 analytes quantitatively determined in a single run
- All analytes validated in compliance with IVDR
- Hydrolysis in just 30 minutes
- Simple hydrolysis at room temperature without a water bath
- Hydrolysis efficiency monitoring in every single patient sample
Assay and Basic Kits for Drugs of Abuse
MassTox® Drugs of Abuse Testing in Urine
| ID / Order No. | Method | Number of sample preparations |
Characteristics |
| 96096 (NEW) | LC-MS/MS | Assay | |
| 96096-BK (NEW) | LC-MS/MS | 400 | Basic Kit with Reaction Vials |
| 96096-A-BK (NEW) | LC-MS/MS | 4x96 | Basic Kit with 96 Deep Well Plates |
| Order No. | Method | Number of tests |
Characteristics |
| 96096-BK (NEW) | LC-MS/MS | 400 | With reaction vials |
| 96096-A-BK (NEW) | LC-MA/MS | 4x96 | With 96 deep well plates |
| 96000 | LC-MS/MS | 400 | With reaction vials |
| 96000/WP | LC-MS/MS | 400 | With 96 well plates |
Parameter Menu of 108 Drugs
Amphetamine, BDB, Butylone, 2C-B, 2C-I, Cathinone, MBDB, MDA, MDEA, MDMA, MDPV, Mephedrone, Methamphetamine, Methaqualone, Methylone, Methylphenidate, PMA, Ritalinic Acid
Allobarbital, Amobarbital, Barbital, Butalbital, Hexobarbital, Pentobarbital, Phenobarbital, Secbutabarbital, Secobarbital, Thiopental
Alprazolam, 7-Aminoclonazepam, 7-Aminoflunitrazepam, 7-Aminonitrazepam, Bromazepam, Brotizolam, Chlordiazepoxide, Clobazam, Clonazepam, Demoxepam, Desalkylflurazepam, Desmethylflunitrazepam, Diazepam, Estazolam, Flunitrazepam, Flurazepam, Lorazepam, Lormetazepam, Medazepam, Midazolam, Nitrazepam, Norclobazam, Nordiazepam, α-OH-Alprazolam, 3-OH-Bromazepam, α-OH-Midazolam, α-OH-Triazolam, Oxazepam, Prazepam, Temazepam, Triazolam
Gabapentin, Pregabalin, Promethazine, Quetiapine
11-Nor-9-Carboxy-Δ9-THC
Benzoylecgonine, Cocaethylene, Cocaine, Norcocaine
Acetylcodeine, Buprenorphine, Codeine, Dihydrocodeine, EDDP, Fentanyl, Hydrocodone, Hydromorphone, Meconin, Meperidine, Methadone, 6-Monoacetylmorphine, Morphine, Naloxone, Naltrexone, Norbuprenorphine, Norcodeine, Norfentanyl, Normeperidine, Nortapentadol, Nortilidine, O-Desmethyltramadol, Oxycodone, Oxymorphone, Papaverine, Propoxyphene, Sufentanil, Tapentadol, Thebaine, Tilidine, Tramadol
Zaleplon, Zolpidem, Zopiclone
Ketamine, LSD, Mescaline, Norketamine, O-H-LSD, PCP
2C-B, 2C-I, 3-OH-Bromazepam, 6-Monoacetylmorphine, 7-Aminoclonazepam, 7-Aminoflunitrazepam, 7-Aminonitrazepam, Acetylcodeine, Allobarbital, Alprazolam, Amobarbital, Amphetamine, Barbital, BDB, Benzoylecgonine, Bromazepam, Brotizolam, Buprenorphine, Butalbital, Butylone, Cathinone, Chlordiazepoxide, Clobazam, Clonazepam, Cocaethylene, Cocaine, Codeine, Demoxepam, Desalkylflurazepam, Desmethylflunitrazepam, Diazepam, Dihydrocodeine, EDDP, Estazolam, Fentanyl, Flunitrazepam, Flurazepam, Gabapentin, Hexobarbital, Hydrocodone, Hydromorphone, Ketamine, Lorazepam, Lormetazepam, LSD, MBDB, MDA, MDEA, MDMA, MDPV, Meconin, Medazepam, Meperidine, Mephedrone, Mescaline, Methadone, Methamphetamine, Methaqualone, Methylone, Methylphenidate, Midazolam, Morphine, Naloxone, Naltrexone, Nitrazepam, Norbuprenorphine, Norclobazam, Norcocaine, Norcodeine, Nordiazepam, Norfentanyl, Norketamine, Normeperidine, Nortapentadol, Nortilidine, O-Desmethyltramadol, O-H-LSD, Oxazepam, Oxycodone, Oxymorphone, Papaverine, PCP, Pentobarbital, Phenobarbital, PMA, Prazepam, Pregabalin, Promethazine, Propoxyphene, Quetiapine, Ritalinic Acid, Secbutabarbital, Secobarbital, Sufentanil, Tapentadol, Temazepam, THC-COOH, Thebaine, Thiopental, Tilidine, Tramadol, Triazolam, Zaleplon, Zolpidem, Zopiclone, α-OH-Alprazolam, α-OH-Midazolam, α-OH-Triazolam
Highlights of the new assay (96096)
Hydrolysis efficiency monitoring for every sample
The new, patented Chromsystems hydrolysis monitoring checks the efficiency of hydrolysis in every individual patient sample and also captures sample-specific effects. This allows samples with incomplete hydrolysis to be identified.
Functional Principle
An isotope-labeled hydrolysis marker (codeine-D6-glucuronide)
is added to each sample. During incubation, this marker – like the other glucuronides in the sample – is cleaved (hydrolysed) by the hydrolysis
enzyme. A hydrolysis reference contains the same amount of hydrolysis marker but is processed without enzyme. As a result, the marker in it remains completely uncleaved.
Comparing the amount of uncleaved marker in the sample and the reference allows the hydrolysis efficiency to be determined. The less uncleaved marker remains in the sample, the more efficient the hydrolysis was.
Hydrolysis duration
Provided no inhibitory effects occur, the optimised enzyme enables complete hydrolysis in just 30 minutes – even for analytes that are difficult to hydrolyse, such as codeine. This helps to ensure reliable and complete hydrolysis.
Coming soon: MassPrep® AddOn Drugs of Abuse Testing
An automated workflow for the MassTox® Drugs of Abuse Testing assay will soon be available on the MassPrep® system. The reagents and plates used are identical to those used in the manual MassTox® Drugs of Abuse Testing assay with 96 deep well plates.
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