Amino Acid Analysis (AAA)

The MassChrom® Amino Acid Analysis (AAA) assays in plasma/serum or urine offer a wide spectrum for your amino acid analysis. You can quantify 48 amino acids in plasma/serum. Or you opt to quantify 52 amino acids and creatinine in urine in one run. Both assays are intended, among other things, for patients with suspected metabolic diseases.

• One chromatographic platform for plasma/serum and urine
• Fast sample preparation without derivatisation
• Shorter run times than HPLC methods
• Excellent separation of all isobaric analytes
• Each analyte with its own internal standard
• Reaction vials or 96 deep well plates

Flexible Analysis: One Assay – 2 Test Modes

Benefit from the flexibility of the Chromsystems assay in plasma/serum: You can either measure 48 amino acids within 20 minutes, or alternatively determine the PKU/MSUD panel within 9 minutes - the choice is yours. The analytes measured with both, the Full Panel and the PKU/MSUD Panel, are leucine, allo-isoleucine, isoleucine, methionine, phenylalanine, tyrosine and valine. Both panels use the identical chromatographic set-up and sample preparation.

52 Amino Acids and Creatinine in One Run

This assay allows the quantitative determination of 52 amino acids/metabolites by LC-MS/MS within 20 minutes. Creatinine is also measured within the same run, which is used for the normalisation of the urinary amino acid concentrations. This eliminates the need for the time-consuming photometric determination and subsequent dilution of the sample. The assay can be used for a number of applications, such as the determination of renal aminoacidurias, and can be ideally combined with our plasma assay without needing to change the chromatographic set-up.

Educational Webinar: Challenging the Status Quo of Amino Acid Analysis in Plasma

Dr Rachel Carling, Scientific Director for Viapath, reports on a study that compares the current gold standard in quantitative amino acid analysis (AAA) - ion exchange chromatography (IEC) with LC-MS/MS.

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