Newborn Screening

The CE-IVD and ready-to-use assays for tandem mass spectrometry allow the determination of amino acids and acylcarnitines from dried blood spot samples. They are used in newborn screening programmes for amino acid and fatty acid metabolic disorders. Assays with and without derivatisation and upgrades for succinylacetone are available.  

• Each analyte safeguarded by its own internal standard
• Fast and robust sample preparation
• Screening for many metabolic disorders in a single run such as PKU (Phenylketonuria), MSUD (Maple Syrup Urine Disease) and tyrosinemia type I

Our assays with derivatisation combine high sensitivity with low interferences. The underivatised assays are characterised by a shorter and faster sample preparation. The methods are available with well plates, or alternatively with well filter plates, reducing the sample prep by one pipetting step. Upgrade sets for the determination of succinylacetone can be easily integrated into our assays and are available for both solutions – with and without derivatisation.

Assay with Derivatisation

Derivatisation (= butylation) of the analytes enhances sensitivity and minimises interference.

Assay without Derivatisation

Without derivatisation, sample preparation is faster and simpler. It can be performed in either 96-well plates or 96-well filter plates. Using 96-well filter plates eliminates the need for a separate transfer step, replacing it with centrifugation and streamlining the workflow.