Newborn Screening

The CE-IVD and ready-to-use assays for LC-MS/MS allow the reliable determination of amino acids and acylcarnitines from dried blood spot samples. They are used in newborn screening programmes for amino acid and fatty acid metabolic disorders. Assays with and without derivatisation and upgrades for succinylacetone are available.  

  • Each analyte safeguarded by its own internal standard
  • Fast and robust sample preparation
  • Screening for many metabolic disorders in a single run such as PKU (Phenylketonuria), MSUD (Maple Syrup Urine Disease) and tyrosinemia type I

Assay Overview for LC-MS/MS Analysis

MassChrom® Amino Acids and Acylcarnitines from Dried Blood

Order No. Derivatisation SUAC-Screening Characteristics Features
55000 Yes 55111 Succinylacetone Upgrade Set 96 Well Plates Highest sensitivity and extremely low interferences
55000/F Yes

 

96 Well Filter Plates Highest sensitivity and extremely low interferences
One pipetting step can be saved by using well filter plates
57000 No 57111 Succinylacetone Upgrade Set 96 Well Plates Efficient and time-saving sample preparation
57000/F No 57111/F Succinylacetone Upgrade Set 96 Well Filter Plates Efficient and time-saving sample preparation
One pipetting step can be saved by using well filter plates

Order No. Derivatisation Characteristics Features
55000 Yes 96 Well Plates Highest sensitivity and extremely low interferences
55000/F Yes 96 Well Filter Plates Highest sensitivity and extremely low interferences
One pipetting step can be saved by using well filter plates
57000 No 96 Well Plates Efficient and time-saving sample preparation
57000/F No 96 Well Filter Plates Efficient and time-saving sample preparation
One pipetting step can be saved by using well filter plates

Our assays with derivatisation combine highest sensitivity with extremely low interferences. The underivatised assays are characterised by a shorter and faster sample preparation. The methods are available with well plates, or alternatively with well filter plates, reducing the sample prep by one pipetting step. Upgrade sets for the determination of succinylacetone can be easily integrated into our assays and are available for both solutions – with and without derivatisation.


Upgrade for Succinylacetone

Succinylacetone is a primary marker to detect tyrosinemia type I in newborns and is part of the newborn screening programs in many countries. With our new assay upgrades you have the opportunity to screen for succinylacetone with both, the derivatised and now also the more time efficient underivatised methods.

Order No. Upgrade Set
55111 Succinylacetone Upgrade Set for 55000
57111 Succinylacetone Upgrade Set for 57000
57111/F Succinylacetone Upgrade Set for 57000/F

 

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