Chronic Alcohol Abuse
Alcohol consumption can be assessed using several complementary biomarkers, each reflecting different metabolic pathways and detection windows. Carbohydrate‑Deficient Transferrin (CDT) is a well‑established indicator of sustained, heavy alcohol intake. Ethylglucuronide (EtG) and Ethylsulphate (EtS) are direct phase‑II metabolites that enable highly sensitive detection of recent drinking. Phosphatidylethanol (PEth), a specific phospholipid formed only in the presence of ethanol, provides an extended and reliable detection window for identifying regular alcohol consumption. Together, these markers offer a comprehensive diagnostic framework ranging from short‑term abstinence monitoring to the evaluation of chronic alcohol use.
Assay Overview
Assay for EtG in Urine (LC-MS/MS)
| Order No. | Assay |
Number of tests | Analysis time |
Characteristics |
| 69000 | MassChrom® Ethyl Glucuronide (EtG), Ethyl Sulfate (EtS) | 400 | 6 min | One step sample prep |
Assays for CDT in Serum (HPLC)
| Order No. | Assay | Number of tests | Analysis time |
Characteristics |
| 54020 54020/500 |
CDT – for binary gradient system | 100 500 |
22 min | Standard method |
| 54030 54030/500 |
CDT – for ternary gradient system | 100 500 |
20 min | Standard method |
| 54330/500 | CDT FE, Fast Elution – for ternary gradient system | 500 | 9.5 min | Standard method |
| 54930/500 | One Step CDT, Fast Elution | 500 | 10 min | With pre-mixed tubes |
| 54730/F | Automated CDT | 6 x 96 | 10 min | With 96 well filter plates |