Parameter Set Neuroleptics 2/EXTENDED 2 - LC-MS/MS

Order No.: 92914/XT2
Parameters:
Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol

Extended parameter menu of 28 analytes
Additional internal standards for enhanced robustness
Part of the continuously updated MassTox® TDM Series A

CE-IVD validated product ready for IVDR within timeframes and transition periods specified by the IVDR 2017/746

Amisulpride

Benperidol

Brexpiprazole

Bromperidol

Cariprazine

Chlorpromazine

Chlorprothixene

Flupentixol

Fluphenazine

Guanfacine

 

Iloperidone

Levomepromazine

Loxapine

Lurasidone

Melperone

Perazine

Perphenazine

Pimozide

Pipamperone

Promethazine

 

Prothipendyl

Sertindole

Sulforidazine

Sulpiride

Thioridazine

Ziprasidone

Zotepine

Zuclopenthixol

Clinical relevance

Neuroleptics are a class of drugs with antipsychotic effects. They counteract hallucinations and delusions, and are primarily used in the treatment of schizophrenia. Their mechanism of action is attributed to their effects on synaptic impulse transmission in the central nervous system. When neuroleptics bind to specific receptors for neurotransmitters (notably dopamine), they prevent impulse transfer and thus inhibit signal transduction.

A key issue in treatment with antipsychotics is finding the right dose, a difficult and potentially time-consuming process because of significant interindividual differences. A lack of response may be pharmacokinetic or pharmacodynamic in origin. Inadequate patient compliance is another factor that may compromise response to treatment.

Studies have demonstrated for some psychoactive drugs that therapeutic drug monitoring improves the likelihood of response to treatment and may help to prevent side effects. This has a positive impact on patient compliance and also has cost-saving potential.

Blood level monitoring is indicated in psychiatry if for instance a medicine is being taken for the first time or dosage adjustment is necessary; if it is suspected that the patient is not taking the drug properly or at all; if adverse reactions occur; if the patient is not responding to treatment; if drug interactions are likely, or if special populations are involved (under 18 or over 65 years of age, patients with learning difficulties, special metabolic circumstances).

In addition to a number of important neuroleptics, this kit can also be used to determine guanfacine, a centrally active alpha-2 receptor agonist. Guanfacine is used in the treatment of attention deficit hyperactivity disorder (ADHD) in patients who are unable to use central stimulants. Since overdosing can cause serious poisoning, patient monitoring is crucial.

To avoid interferences and enable a clear analysis, the neuroleptics were divided into two Parameter Sets, Neuroleptics 1/EXTENDED and Neuroleptics 2/EXTENDED 2.

 

MassTox® TDM Series A

The MassTox® TDM Series A is a modular system that enables the determination of 200 analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® TDM Basic Kit A
• Specific MassTox® TDM Parameter Set (13 different parameter sets available)
• Analytical column MassTox® TDM MasterColumn® A

More information about MassTox® TDM Series A

 

MassSTAR

For this parameter set a CE-IVD compliant workflow method is also available using the MassSTAR to automate the sample preparation.

More information about MassSTAR

More Information
Method of Analysis LC-MS/MS
Please note The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.
Lower Limit of Quantitation 0.1 – 29.0 µg/l
Upper Limit of Quantification 24 – 2500 µg/l
Intraassay CV = 1.2 – 8.8 %
Interassay CV = 2.8 – 10.0 %
Recovery 96 – 107 %
Specimen Serum/Plasma
Sample Preparation
  • Reconstitute the Internal Standard Mix
  • Add 800 µl Internal Standard Mix to 12 ml Precipitation Reagent (= mixture A).
  • Pipette 50 µl sample/calibrator/MassCheck® control into a 1.5 ml reaction vial.
  • Add 25 µl Extraction Buffer, mix briefly (vortex) and incubate 2 min.
  • Add 250 µl of mixture A, mix 30 s (vortex) and centrifuge 5 min.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity.
Run Time 5 min
Injection Volume 0.2 – 50 µl
Ionisation ESI positive
MS/MS Mode MRM
Additional Info We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.
Parameters Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol
The following components are included in the kit:
The following products are not included in the kit but are required for the application of the method:
As a customer please login or register to gain full access.

Amisulpride

Benperidol

Brexpiprazole

Bromperidol

Cariprazine

Chlorpromazine

Chlorprothixene

Flupentixol

Fluphenazine

Guanfacine

 

Iloperidone

Levomepromazine

Loxapine

Lurasidone

Melperone

Perazine

Perphenazine

Pimozide

Pipamperone

Promethazine

 

Prothipendyl

Sertindole

Sulforidazine

Sulpiride

Thioridazine

Ziprasidone

Zotepine

Zuclopenthixol

Clinical relevance

Neuroleptics are a class of drugs with antipsychotic effects. They counteract hallucinations and delusions, and are primarily used in the treatment of schizophrenia. Their mechanism of action is attributed to their effects on synaptic impulse transmission in the central nervous system. When neuroleptics bind to specific receptors for neurotransmitters (notably dopamine), they prevent impulse transfer and thus inhibit signal transduction.

A key issue in treatment with antipsychotics is finding the right dose, a difficult and potentially time-consuming process because of significant interindividual differences. A lack of response may be pharmacokinetic or pharmacodynamic in origin. Inadequate patient compliance is another factor that may compromise response to treatment.

Studies have demonstrated for some psychoactive drugs that therapeutic drug monitoring improves the likelihood of response to treatment and may help to prevent side effects. This has a positive impact on patient compliance and also has cost-saving potential.

Blood level monitoring is indicated in psychiatry if for instance a medicine is being taken for the first time or dosage adjustment is necessary; if it is suspected that the patient is not taking the drug properly or at all; if adverse reactions occur; if the patient is not responding to treatment; if drug interactions are likely, or if special populations are involved (under 18 or over 65 years of age, patients with learning difficulties, special metabolic circumstances).

In addition to a number of important neuroleptics, this kit can also be used to determine guanfacine, a centrally active alpha-2 receptor agonist. Guanfacine is used in the treatment of attention deficit hyperactivity disorder (ADHD) in patients who are unable to use central stimulants. Since overdosing can cause serious poisoning, patient monitoring is crucial.

To avoid interferences and enable a clear analysis, the neuroleptics were divided into two Parameter Sets, Neuroleptics 1/EXTENDED and Neuroleptics 2/EXTENDED 2.

 

MassTox® TDM Series A

The MassTox® TDM Series A is a modular system that enables the determination of 200 analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® TDM Basic Kit A
• Specific MassTox® TDM Parameter Set (13 different parameter sets available)
• Analytical column MassTox® TDM MasterColumn® A

More information about MassTox® TDM Series A

 

MassSTAR

For this parameter set a CE-IVD compliant workflow method is also available using the MassSTAR to automate the sample preparation.

More information about MassSTAR

More Information
Method of Analysis LC-MS/MS
Please note The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.
Lower Limit of Quantitation 0.1 – 29.0 µg/l
Upper Limit of Quantification 24 – 2500 µg/l
Intraassay CV = 1.2 – 8.8 %
Interassay CV = 2.8 – 10.0 %
Recovery 96 – 107 %
Specimen Serum/Plasma
Sample Preparation
  • Reconstitute the Internal Standard Mix
  • Add 800 µl Internal Standard Mix to 12 ml Precipitation Reagent (= mixture A).
  • Pipette 50 µl sample/calibrator/MassCheck® control into a 1.5 ml reaction vial.
  • Add 25 µl Extraction Buffer, mix briefly (vortex) and incubate 2 min.
  • Add 250 µl of mixture A, mix 30 s (vortex) and centrifuge 5 min.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity.
Run Time 5 min
Injection Volume 0.2 – 50 µl
Ionisation ESI positive
MS/MS Mode MRM
Additional Info We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.
Parameters Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol
The following components are included in the kit:
The following products are not included in the kit but are required for the application of the method:
As a customer please login or register to gain full access.