MassTox® TDM Series A
Modular System for Therapeutic Drug Monitoring
- 200 Parameters (continuously extended)
- 1 Analytical column – 1 sample prep
- Almost all parameters safeguarded by internal standards
- 3PLUS1® or 6PLUS1® Multilevel Calibrator Sets and MassCheck® plasma controls
- CSQUANT data mining software
- Robotic solution for more than 100 parameters with MassSTAR
The Three Components of MassTox® TDM Series A
Master Column
One analytical column for all. No column switching required.
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Basic Kit
Contains all components required for a complete sample preparation and all necessary mobile phases.
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Parameter Sets
Parameter menu of 200 analytes is divided in 13 parameter sets. All of them contain all relevant calibrators, quality controls and internal standards.
Example of a Parameter Set: MassTox® Neuroleptics 1/EXTENDED
Identical Sample Preparation for all Parameter Sets:
- Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent (= mixture A).
- Pipette 50 μl sample/calibrator/MassCheck® control
into a 1.5 ml reaction vial. - Add 25 μl Extraction Buffer, mix briefly (vortex)
and incubate 2 min. - Add 250 μl of mixture A, mix 30 s (vortex) and centrifuge 5 min.
- Dilute supernatant with Dilution Buffer (depending on instrument sensitivity) and inject into LC-MS/MS system.
The information on the sample preparation presented here is not sufficient for use in the laboratory. For a detailed step by step description, please refer to the instruction manual.
13 Parameter Sets available:
- Antiarrhythmic Drugs
- Antidepressants 1/EXTENDED
- Antidepressants 2/ Psychostimulants/ EXTENDED
- Antiepileptic Drugs XT2, All-in-One Method
- Anti-HIV Drugs
- Antimycotic Drugs
- Benzodiazepines 1
- Benzodiazepines 2
- Mycophenolic Acid
- Neuroleptics 1/EXTENDED
- Neuroleptics 2/EXTENDED 2
- Tricyclic Antidepressants TCA1
- Tricyclic Antidepressants TCA2
Parameter Menu
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Acebutolol, Ajmaline, Amiodarone, Desethylamiodarone, Aprindine, Atenolol, Bisoprolol, Diltiazem, Disopyramide, Dronedarone, Debutyldronedarone, Flecainide, Flunarizine, Gallopamil, Lidocaine, Metoprolol, Mexiletine, Propafenone, Propranolol, Quinidine, Hydroquinidine, Sotalol, Tocainide, Verapamil, Norverapamil |
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Antidepressants 1/EXTENDED (92913/XT) Citalopram, N-Desmethylcitalopram, Duloxetine, Fluoxetine, Desmethylfluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylmirtazapine, Paroxetine, Sertraline, N-Desmethylsertraline, Venlafaxine, O-Desmethylvenlafaxine |
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Antidepressants 2/ Psychostimulants/EXTENDED (92915/XT) Atomoxetine, Bupropion, Erythro-Dihydrobupropion, Threo-Dihydrobupropion, Hydroxybupropion, Clomethiazole, Dosulepin, N-Desmethyldosulepin, Methylphenidate, Mianserin, Milnacipran, Moclobemide, Opipramol, Reboxetine, Ritalinic acid, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine |
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Antiepileptic Drugs XT2, All-in-One Method (92921-XT2) Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, 10-OH-Carbamazepine, Cenobamate, N-Desmethylmesuximide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Oxcarbazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic acid, Vigabatrin, Zonisamide |
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Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Saquinavir |
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Antimycotic Drugs/EXTENDED (92922/XT) Anidulafungin, Caspofungin, Fluconazole, 5-Flucytosine, Isavuconazole, Itraconazole, Hydroxyitraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole |
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Chlordiazepoxide, Clobazam, Norclobazam, Demoxepam, Diazepam, Nordiazepam, Medazepam, Midazolam, 1-OH-Midazolam, Oxazepam, Prazepam, Temazepam, Tetrazepam |
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Alprazolam, Bromazepam, Clonazepam, Flunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Nitrazepam, Triazolam |
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Mycophenolic acid, Mycophenolic acid glucuronide |
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Neuroleptics 1/EXTENDED (92912/XT) Aripiprazole, Dehydroaripiprazole, Clozapine, N-Desmethylclozapine, Haloperidol, Olanzapine, N-Desmethylolanzapine, Quetiapine, Norquetiapine, Risperidone, 9-OH-Risperidone |
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Neuroleptics 2/EXTENDED 2 (92914/XT2) Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol |
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Tricyclic Antidepressants TCA1 (92919) Amitriptyline, Desipramine, Doxepin, Nordoxepin, Imipramine, Nortriptyline |
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Tricyclic Antidepressants TCA2 (92920) Clomipramine, Norclomipramine, Maprotiline, Normaprotiline, Protriptyline, Trimipramine, Nortrimipramine |
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