MassTox® TDM Series A

Unique Modular System for Therapeutic Drug Monitoring

200 Parameters (continuously extended)
1 Analytical column – 1 sample prep
Almost all parameters safeguarded by internal standards
3PLUS1® or 6PLUS1® Multilevel Calibrator Sets
MassCheck® plasma controls

The Three Components of MassTox® TDM Series A

Master Column
One analytical column for all. No column switching required.

Basic Kit
Contains all components required for a complete sample preparation and all necessary mobile phases.

Parameter Sets
Parameter menu of 200 analytes is divided in 13 parameter sets. All of them contain all relevant calibrators, quality controls and internal standards.

Example of a Parameter Set: MassTox® Neuroleptics 1/EXTENDED

Identical Sample Preparation for all Parameter Sets:

Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent (= mixture A).
Pipette 50 μl sample/calibrator/MassCheck® control
into a 1.5 ml reaction vial.
Add 25 μl Extraction Buff er, mix briefly (vortex)
and incubate 2 min.
Add 250 μl of mixture A, mix 30 s (vortex) and centrifuge 5 min.
Dilute supernatant with Dilution Buff er (depending on instrument sensitivity) and inject into LC-MS/MS system.

13 Parameter Sets available:

Antiarrhythmic Drugs
Antidepressants 1/EXTENDED
Antidepressants 2/ Psychostimulants/ EXTENDED
Antiepileptic Drugs All-in-One Method
Anti-HIV Drugs
Antimycotic Drugs
Benzodiazepines 1
Benzodiazepines 2
Mycophenolic Acid
Neuroleptics 1/EXTENDED
Neuroleptics 2/EXTENDED 2
Tricyclic Antidepressants TCA1
Tricyclic Antidepressants TCA2

Parameter Menu

Antiarrhythmic Drugs (92923)

Acebutolol, Ajmaline, Amiodarone, Desethylamiodarone, Aprindine, Atenolol, Bisoprolol, Diltiazem, Disopyramide, Dronedarone, Debutyldronedarone, Flecainide, Flunarizine, Gallopamil, Lidocaine, Metoprolol, Mexiletine, Propafenone, Propranolol, Quinidine, Hydroquinidine, Sotalol, Tocainide, Verapamil, Norverapamil

Antidepressants 1/EXTENDED (92913/XT)

Citalopram, N-Desmethylcitalopram, Duloxetine, Fluoxetine, Desmethylfluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylmirtazapine, Paroxetine, Sertraline, N-Desmethylsertraline, Venlafaxine, O-Desmethylvenlafaxine

Antidepressants 2/ Psychostimulants/EXTENDED (92915/XT)

Atomoxetine, Bupropion, Erythro-Dihydrobupropion, Threo-Dihydrobupropion, Hydroxybupropion, Clomethiazole, Dosulepin, N-Desmethyldosulepin, Methylphenidate, Mianserin, Milnacipran, Moclobemide, Opipramol, Reboxetine, Ritalinic acid, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine

Antiepileptic Drugs All-in-One Method (92921/XT)

Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, 10-OH-Carbamazepine, 10,11-Dihydroxycarbamazepine, N-Desmethylmesuximide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Oxcarbazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic acid, Vigabatrin, Zonisamide

Anti-HIV Drugs (92924)

Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Saquinavir

Antimycotic Drugs/EXTENDED (92922/XT)

Amphotericin B*, Anidulafungin, Caspofungin, Fluconazole, 5-Flucytosine, Isavuconazole, Itraconazole, Hydroxyitraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole

Benzodiazepines 1 (92917)

Chlordiazepoxide, Clobazam, Norclobazam, Demoxepam, Diazepam, Nordiazepam, Medazepam, Midazolam, 1-OH-Midazolam, Oxazepam, Prazepam, Temazepam, Tetrazepam

Benzodiazepines 2 (92918)

Alprazolam, Bromazepam, Clonazepam, Flunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Nitrazepam, Triazolam

Mycophenolic Acid (92916)

Mycophenolic acid, Mycophenolic acid glucuronide

Neuroleptics 1/EXTENDED (92912/XT)

Aripiprazole, Dehydroaripiprazole, Clozapine, N-Desmethylclozapine, Haloperidol, Olanzapine, N-Desmethylolanzapine, Quetiapine, Norquetiapine, Risperidone, 9-OH-Risperidone

Neuroleptics 2/EXTENDED 2 (92914/XT2)

Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol

Tricyclic Antidepressants TCA1 (92919)

Amitriptyline, Desipramine, Doxepin, Nordoxepin, Imipramine, Nortriptyline

Tricyclic Antidepressants TCA2 (92920)

Clomipramine, Norclomipramine, Maprotiline, Normaprotiline, Protriptyline, Trimipramine, Nortrimipramine

* For Amphotericin B only qualitative information can be obtained, but data are not CE-IVD compliant.