ECMO treatment was associated with significantly reduced serum concentrations of specific antibiotics. Future studies are needed to assess the pharmacokinetic characteristics of antibiotics in ICU patients on ECMO support. Antbiotics were measured with the Chromsystems HPLC assay.
The present results indicate that psychotropic drugs with certain characteristics bind to LDL/VLDL in blood. This further implies that lipoproteins could play an important role in drug transport. Drugs were measured with MassTox Series A Calibrator Sets
The present results indicate that psychotropic drugs with certain characteristics bind to LDL/VLDL in blood. This further implies that lipoproteins could play an important role in drug transport.. Measured with MassTox TDM Series A
Data indicate that the interindividual variation in saliva to serum concentrations is rather high, whereas the intraindividual variation is fairly low. Methylphenidate and ritalinic acid were measured with MassTox TDM Series A.
Considering the percentage of therapeutic azole plasma trough levels and the intrapatient variability, posaconazole tablets seem to be the most reliable choice of antimycotic therapy in lung transplant recipients. MassTox TDM Series A was used with antimycotics parameter set.
The findings suggest that the effects of AED monotherapy on one-carbon metabolism may induce specific regions of DNA hypomethylation. Chromsystems HPLC was used for the determination of valproic acid and lamotrigine.
Carbamazepine monotherapy may be a relatively safe and cost effective treatment option for women with focal epilepsy syndromes during pregnancy. Carbamazepine and ist epoxide was measured by the Chromsystems HPLC assay
An increase in changes in the oral clearence of lamotrigine may correspond to decreases in lamotrigine blood concentrations necessitating the need for more frequent dosage adjustments and closer monitoring in some pregnant women with epilepsy. Lamotrigine was measured by HPLC with an Chromsystems assay.
Aim of the study was to confirm the efficacy and tolerability of ziprasidone as adjunctive therapy in bipolar patients partially responding to clozapine or with persisting negative symptoms, overweight, or with metabolic syndrome. Clozapine and active metabolites were measured with an HPLC assay from Chromsystems
In conclusion, potential factors like younger age, prophylaxis, underlying hematological malignancy, BMI, and concomitant PPI should be considered within the algorithm of voriconazole treatment.Voriconazole plasma concentrations were measured with an HPLC assay.
This pilot study demonstrates the utility of TDM of antiepileptic medications throughout pregnancy and highlights the use of LC-MS/MS in performing hese measures. Additionally, the multiplexed MRM assay used in the study allows for the analysis of several different AEDs in a single run adding efficiencies of staffing and instrument times in the process.
A PPK model of lamotrigine (LTG) in Chinese children with epilepsy was successfully established with NONMEM. LTG concentrations can be predicted accurately by this model. The model may be very useful for establishing initial LTG dosage guidelines. LTG was measured with Chromsystems HPLC assay.
. A possible pharmacokinetic interaction between clozapine and aripiprazole does not account for the improved clinical benefit obtained after aripiprazole augmentation, according to the study that used a Chromsystems HPLC for the determination of clozapone and its metabolites.
This review helps in strengthening our understanding of the small-molecule fragmentation in MS–MS. In the case of AEDs, the structure proposals for the product ions can not only be confirmed with accurate-m/z data from high-resolution MS instruments, but also by studying m/z-shifts of products ions of the stable-isotope labeled analogues, that are frequently used as internal standard.
This study highlights a clinically relevant systematic overestimation of MPA concentration by EMIT, supporting the switch to LC–MS/MS techniques for TDM purpose. MPA was measured with the MassTOX Series A assay.
For ease of handling and minimization of blood drawing times, the authors assume that tubes containing separator gel can be used for therapeutic drug monitoring of high hydrophilic drugs. In contrast lipophilic compounds showing logP higher than 3 and/or CF>20 should be critically considered and validated by extensive stability studies. Concentrations of selected drugs were measured with MassTox TDM Series A, AED parameter set.
MassTox TDM Parameter Set AD2/psychostimulants is methodogically and analytically suitable for the determination of MPH and its metabolite ritalinic acid.
Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements.