Vitamin B12/MMA

Title Summary Year
Vitamin B12 deficiency prevalence and associated biomarkers in type 2 Diabetes (T2DM) treated with metformin: biochemical assessment in a series of 106 patients The 2018 ADA Clinical Practice Recommendations endorse screening Metformin users for vitamin B12 deficiency. In our series, diabetic patients treated by metformin had B12 deficiency in 17% of cases (total B12) and only in 8.5% (HTC). MMA measured with Chromsystems assay.  2019

Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements. 

Title Summary Year
Thomas L. (ed)- Labor und Diagnose, 8th edition, TH books (2012) Book with reference ranges.  2012
The Clinical Evaluation of Cobalamin Deficiency by Determination of Methylmalonic Acid in Serum or Urine Is Not Invalidated by the Presence of Heterozygous Methylmalonic-Acidaemia Paper discusses the usefulness of measurement of methylmalonic acid in serum or urine for the clinical evaluation of cobalamin deficiency and the reference values.  1990