Maternal virilization in hyperreactio luteinalis is a rare, self-limited condition. Interventions during pregnancy are usually not necessary unless surgical complications, do occur. Virilization cannot be predicted by the level of circulating testosterone. Androstenedione, progesterone, cortisol, dehydroepiandrosterone sulfate (DHEAS), estradiol, 17-OH-progesterone and testosterone measured with MassChrom Steroids.
This report is the first to demonstrate extraordinary sensitivity of adrenal cortex cells to ferroptosis dependent on their active steroid synthetic pathways. Mitotane does not induce this form of cell death in ACC cells. Measured with MassChrom Steroids.
The authors characterized the immune response underlying a classical, male-biased parasitic disease and identified a prominent role of classical monocytes expressing a typical cytokine set. Hormone analysis was performed with MassChrom Steroids.
The global index of 11HSD activity, assessed by the circulating cortisol:cortisone ratio, was related to high blood pressure and fasting plasma glucose and may serve as a proxy to global 11HSD activity. Measured with MassChrom Steroids assay.
Prepubertal DHEAS in normal girls is associated with earlier thelarche, pubarche, and menarche, and a mild androgen increase throughout puberty. . Concentrations of DHEAS, androstenedione17-OH progesterone (17-OHP), and testosterone were analyzed by MassChrom Steroids assay.
Primary canine adrenocortical cell culture may be a useful model system for drug testing. For the treatment of Cushings syndrome (CS), AA may to be superior to other steroidogenesis inhibitors due to its low toxicity. Steroids were measured with the MassChrom Steroids assay.
This clinical study invesigtates dihydrotestosterone as a predictor for mortality of pneumonia. aldosterone, progesterone, OH-progesterone, DHEA, DHEA-S, testosterone, androstenedione, and dihydrotestosterone are measured with MassChrom Steroids
This prospective pilot study demonstrated that metyrapone is effective in normalizing biochemical and clinical parameters in patients with CS due to adrenal adenoma before surgical intervention, with minimal side effects.. cortisol, 11-deoxycortisol, DHEAS, testosterone and androstenedione levels by LC–MS/MS with MassChrom Steroids
results support the hypothesis that nandrolone is able to modify testosterone production by interfering with StAR and CYP17A1 expression in Leydig cells. MassChrom Steroids was used for the determination of steroid hormones.
The study concludes that the determination of testosterone by immunoassay in nondiabetic young men with obesity yields lower concentrations than by LC-MS/MS, resulting in an equivocal increased diagnosis of hypoandrogenemia, which could lead to inaccurate diagnosis and unnecessary treatment. MassChrom Steroids was used.
The results confirm that LC-MS/MS is more sensitive than immunoassays in the diagnosis of PCOS with LC-MS/MS detecting higher levels of testosterone and androstenedione. Furthermore testosterone by LC-MS/MS correlates with adverse metabolic parameters. MassChrom Steroids was used for the determination of testosterone and androstenedione.
The global index of 11HSD activity, assessed by the circulating cortisol:cortisone ratio, was related to high blood pressure and fasting plasma glucose and may serve as a proxy to global 11HSD activity. Serum cortisol and cortisone were measured with MassChrom Steroids.
Evaluated immunoassays failed to satisfy requirements for methods’ comparability and produced significant analytical biases in respect to the LC-MS/MS assay, especially at low concentrations. LC-MS/MS assay used was MassChrom Steroids
Although the patient may represent an isolated case of primary aldosteronism, immunoassay interference leading to misdiagnosis of primary aldosteronism, unnecessary AVS and potentially wrongful removal of an adrenal, it is also possible that such inaccuracies may impact the diagnostic process and treatment for other patients. Measured with MassChrom Steroids and compared with other assays.
Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements.
Thomas L. (ed)- Labor und Diagnose, 8th edition, TH books (2012)
Book with reference values
Shackleton C. (2008) Genetic disorders of steroid metabolism diagnosed by mass spectrometry. In: Blau N Duran M Gibson KM (eds.) Laboratory guide to the methods in biochemical genetics p. 549-606