Therapeutic Drug Monitoring
We offer complete solutions in therapeutic drug monitoring (TDM) covering assays as well as calibrators and controls. All of our LC-MS/MS and HPLC assays are validated and comply with relevant regulatory rules.
- CE-IVD validated methods
- Series A with 200 drugs with one column and sample preparation
- OneMinute Test for immunosuppressants
- Robotic solution for more than 100 drugs
TDM with LC-MS/MS or HPLC
More information on MassTox® TDM Series A
Master Column
One analytical column for all Parameter Sets. No column switching required.
| Order No. | Product |
| 92110 | MassTox® TDM MasterColumn® A |
Basic Kits
Contain all components required for a complete sample preparation and all necessary mobile phases.
| Order No. | Product |
| 92111/200 | Basic Kit A for 200 tests |
| 92111/1000 | Basic Kit A for 1000 tests |
| 92111/1000/F | Basic Kit A for 1000 tests, for sample preparation with 96 well filter plates |
Parameter Sets in Serum/Plasma
Contain all relevant calibrators, quality controls and internal standards.
| Order No. | Product |
| 92923 | Antiarrhythmic Drugs |
| 92913/XT | Antidepressants 1/EXTENDED |
| 92915/XT | Antidepressants 2/Psychostimulants/EXTENDED |
| 92921-XT2 | Antiepileptic Drugs XT2, All-in-One Method  |
| 92924 | Anti-HIV Drugs |
| 92922/XT | Antimycotic Drugs/EXTENDED |
| 92917 | Benzodiazepines 1 |
| 92918 | Benzodiazepines 2 |
| 92916 | Mycophenolic Acid |
| 92912/XT | Neuroleptics 1/EXTENDED |
| 92914/XT2 | Neuroleptics 2/EXTENDED 2 |
| 92919 | Tricyclic Antidepressants TCA 1 |
| 92920 | Tricyclic Antidepressants TCA 2 |
Parameter Overview
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Acebutolol, Ajmaline, Amiodarone, Desethylamiodarone, Aprindine, Atenolol, Bisoprolol, Diltiazem, Disopyramide, Dronedarone, Debutyldronedarone, Flecainide, Flunarizine, Gallopamil, Lidocaine, Metoprolol, Mexiletine, Propafenone, Propranolol, Quinidine, Hydroquinidine, Sotalol, Tocainide, Verapamil, Norverapamil |
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Antidepressants 1/EXTENDED (92913/XT) Citalopram, N-Desmethylcitalopram, Duloxetine, Fluoxetine, Desmethylfluoxetine, Fluvoxamine, Mirtazapine, N-Desmethylmirtazapine, Paroxetine, Sertraline, N-Desmethylsertraline, Venlafaxine, O-Desmethylvenlafaxine |
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Antidepressants 2/ Psychostimulants/EXTENDED (92915/XT) Atomoxetine, Bupropion, Erythro-Dihydrobupropion, Threo-Dihydrobupropion, Hydroxybupropion, Clomethiazole, Dosulepin, N-Desmethyldosulepin, Methylphenidate, Mianserin, Milnacipran, Moclobemide, Opipramol, Reboxetine, Ritalinic acid, Tianeptine, Tranylcypromine, Trazodone, Vilazodone, Vortioxetine |
|
Antiepileptic Drugs XT2, All-in-One Method (92921-XT2) Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, 10-OH-Carbamazepine, Cenobamate, N-Desmethylmesuximide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Oxcarbazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic acid, Vigabatrin, Zonisamide |
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Amprenavir, Atazanavir, Darunavir, Delavirdine, Efavirenz, Elvitegravir, Etravirine, Indinavir, Lopinavir, Maraviroc, Nelfinavir, Nelfinavir-M8, Nevirapine, Raltegravir, Rilpivirine, Ritonavir, Saquinavir |
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Antimycotic Drugs/EXTENDED (92922/XT) Anidulafungin, Caspofungin, Fluconazole, 5-Flucytosine, Isavuconazole, Itraconazole, Hydroxyitraconazole, Ketoconazole, Micafungin, Posaconazole, Voriconazole |
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Chlordiazepoxide, Clobazam, Norclobazam, Demoxepam, Diazepam, Nordiazepam, Medazepam, Midazolam, 1-OH-Midazolam, Oxazepam, Prazepam, Temazepam, Tetrazepam |
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Alprazolam, Bromazepam, Clonazepam, Flunitrazepam, Flurazepam, Desalkylflurazepam, Lorazepam, Lormetazepam, Nitrazepam, Triazolam |
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Mycophenolic acid, Mycophenolic acid glucuronide |
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Neuroleptics 1/EXTENDED (92912/XT) Aripiprazole, Dehydroaripiprazole, Clozapine, N-Desmethylclozapine, Haloperidol, Olanzapine, N-Desmethylolanzapine, Quetiapine, Norquetiapine, Risperidone, 9-OH-Risperidone |
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Neuroleptics 2/EXTENDED 2 (92914/XT2) Amisulpride, Benperidol, Brexpiprazole, Bromperidol, Cariprazine, Chlorpromazine, Chlorprothixene, Flupentixol, Fluphenazine, Guanfacine, Iloperidone, Levomepromazine, Loxapine, Lurasidone, Melperone, Perazine, Perphenazine, Pimozide, Pipamperone, Promethazine, Prothipendyl, Sertindole, Sulforidazine, Sulpiride, Thioridazine, Ziprasidone, Zotepine, Zuclopenthixol |
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Tricyclic Antidepressants TCA1 (92919) Amitriptyline, Desipramine, Doxepin, Nordoxepin, Imipramine, Nortriptyline |
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Tricyclic Antidepressants TCA2 (92920) Clomipramine, Norclomipramine, Maprotiline, Normaprotiline, Protriptyline, Trimipramine, Nortrimipramine |
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MassTox® Immunosuppressants in Whole Blood
| Order No. | Assay | Run Time |
Number of tests | Parameters | Characteristics |
| 93000 93000/1200 |
Immunosuppressants | 4.5 min | 400 1200 |
Cyclosporin A Everolimus Sirolimus Tacrolimus |
|
| 93900/400 93900/1200 |
Immunosuppressants – ONEMinute Test | 1 – 2 min | 400 1200 |
Shorter run time | |
| 93900/1200/DWP | Immunosuppressants – ONEMinute Test | 1 – 2 min | 1200 | Shorter run time For sample preparation with 96 deep well extraction plates |
Immunosuppressants Assays Now Licensed in Canada:
Chromsystems has obtained a class III license for the MassTox® Immunosuppressant kits in whole blood, including the One Minute Test. This assay allows the determination of the four immunosuppressants with a run time of only 1-2 minutes per sample.
Overview TDM Assays by HPLC
| Order No. | Assay | Parameters | Automation |
| 61000 | Antibiotics in Serum/Plasma | Ampicillin, cefepime, ceftazidime, linezolid, meropenem, piperacillin, sulbactam, tazobactam | |
| 25000 | Amiodarone and Desmethylamiodarone in Serum/Plasma | Amiodarone, desethylamiodarone | |
| 22000/F |
Antiepileptic Drugs in Serum/Plasma Fast Elution |
carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, lamotrigine, phenobarbital, phenytoin, primidone | Gilson Flexus®/ASPEC® |
| 22000/HR |
Antiepileptic Drugs in Serum/Plasma High Resolution |
10-OH-carbamazepine, carbamazepine, carbamazepine-10,11-epoxide, ethosuximide, lamotrigine, oxcarbamazepine (Trileptal®), phenobarbital, phenytoin, primidone, sultiame, zonisamide | Gilson Flexus®/ASPEC® |
| 49000 | Benzodiazepines and Tricyclic Antidepressants in Serum/Plasma | Alprazolam, amitriptyline, bromazepam, chlordiazepoxide, clobazam, clomipramine, clonazepam, clozapine, desipramine, diazepam, doxepin, flunitrazepam, imipramine, maprotiline, nitrazepam, norclobazam, norclomipramine, norclozapine, nordiazepam, nordoxepin, nortriptyline, oxazepam, trimipramine | Gilson Flexus®/ASPEC® |
| 27037 | Itraconazole, Posaconazole and Voriconazole in Serum/Plasma | Itraconazole, hydroxyitraconazole, posaconazole, voriconazole | |
| 24000 | Levetiracetam (Keppra®) in Serum/Plasma | Levetiracetam (Keppra®) | |
| 46000 | Mycophenolic Acid in Plasma/Serum | Mycophenolic acid | |
| 26000 | Olanzapine and Desmethylolanzapine in Serum/Plasma | Olanzapine, desmethylolanzapine, quetiapine | |
| 21000 | Rufinamide, Felbamate and Lacosamide in Serum/Plasma | Eslicarbazepine, felbamate, lacosamide, N-desmethylmesuximide, rufinamide |