Parameter Set Antiarrhythmic Drugs - LC-MS/MS

Clinical relevance

Antiarrhythmic drugs are used for the treatment of cardiac arrhythmia to reduce their frequency or intensity. The severity of ventricular and supraventricular rhythm disturbances ranges from harmless extra beats through to complex multiple blows and life-threatening tachycardia. By using antiarrhythmic agents, it is possible to restore a normal electrical cardiac activity. Since antiarrhythmic drugs are an inhomogeneous group, in their chemistry and mechanisms of action, various side effects and drug interactions have to be considered. Their use should be monitored by ECG monitoring, electrolyte and plasma level determinations, in particular when starting new drug regimens. As each antiarrhythmic drug possesses a pro-arrhythmic potential, it also can cause cardiac arrhythmia. Furthermore, there are drug-drug interactions between the different antiarrhythmics, and therefore, combinations should be taken with extreme caution as well as with due attention to the side-effects and interaction profiles. For these reasons cardiac arrhythmia are often only treated with medication when they are very dangerous or associated with a high burden for the patient.

MassTox® TDM Series A

The MassTox® TDM Series A is a modular system that enables the determination of 200 analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® TDM Basic Kit A
• Specific MassTox® TDM Parameter Set (13 different parameter sets available)
• Analytical column MassTox® TDM MasterColumn® A

More information about MassTox® TDM Series A