Parameter Set Antidepressants 2/ Psychostimulants/EXTENDED for automated sample preparation on Chromsystems MassSTAR

Clinical relevance

Antidepressants are a group of chemically different drugs used to treat depression, obsessive-compulsive disorder, anxiety disorders and chronic pain. They modify the metabolism of the body's own neurotransmitters, primarily those of serotonin and norepinephrine, or react with their receptors.

Psychostimulants increase the activity of the central nervous system. Among other things, they eliminate fatigue, reduce the need for sleep, increase the ability to concentrate and inhibit the appetite.
This parameter set also includes psychostimulants such as methylphenidate (Ritalin®). The amphetamine-like substance is mainly used in the treatment of attention deficit/hyperactivity disorder (ADHD). Methylphenidate inhibits the reuptake of dopamine and noradrenaline, thus increasing their concentration in the synaptic cleft and enhancing the activity of the sympathetic nervous system. Atomoxetine, which has a chemical structure similar to fluoxetine, is another drug used to treat ADHD. In Germany, atomoxetine is approved for ADHD and is not subject to the controlled-substances law of Germany (Betäubungsmittelgesetz BtMG). Mianserin, reboxetine, and trazodone are prescribed for depression.

MassTox® TDM Series A

The MassTox® TDM Series A is a modular system that enables the determination of 200 analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® TDM Basic Kit A
• Specific MassTox® TDM Parameter Set (13 different parameter sets available)
• Analytical column MassTox® TDM MasterColumn® A

More information about MassTox® TDM Series A

MassSTAR

For this parameter set Chromsystems offers a CE-IVD compliant workflow method using the MassSTAR to automate the sample preparation.

More information about MassSTAR

Detailed performance evaluation data can be found in the appendices of the instruction manual.