TDM of clinically relevant antibiotics

Quantitative test - fast and easy
Chromsystems offers a CE-IVD method for the quantitative determination of ampicillin, cefepime, ceftazidime, linezolid, meropenem and piperacillin in human serum and plasma samples. The robust HPLC method is simple to perform and easy to establish - our support team will also assist you.

Patient-specific dosing
Accurate monitoring of the antibiotics concentration by TDM can prevent suboptimal dosing and allows tailoring the drug regimen for each specific patient.

Ideal for antibiotic stewardship programs (ASP)
An increasing number of scientific studies show that stewardship programs can improve the treatment of infectious diseases. [1] These programs also intend to minimise antibiotic resistance [2] while saving costs. [3, 4]

This article discusses the importance of appropriate drug concentrations in antibiotic therapies to and help prevent over- and underdosing. This approach also reduces the risk of new multidrug resistant strains emerging and helps to provide the most effective drug dose to the patient.

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[1] Malani AN et al. (2013) “Clinical and economic outcomes from a community hospital's antimicrobial stewardship program.” Am. J. Infect. Control. 41(2):145-8. doi: 10.1016/j.ajic.2012.02.021.

[2] DiazGranados CA et al. (2012) Prospective audit for antimicrobial stewardship in intensive care: impact on resistance and clinical outcomes. Am. J. Infect. Control. 40(6):526-9. doi: 10.1016/j.ajic.2011.07.011.

[3] Sick AC et al. (2013) „Sustained savings from a longitudinal cost analysis of an internet-based preapproval antimicrobial stewardship program.” Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. 34(6):573-580. doi: 10.1086/670625.

[4] Roberts RR et al. (2009) “Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.” Clin. Infect. Dis. 2009 49(8):1175-84. doi: 10.1086/605630.