Sample Prep Set Total Metanephrines (free + conjugated) with Sample Clean Up Columns
Isotopically labelled internal standard for each analyte
6PLUS1® Multilevel Calibrator Set and MassCheck® controls
CE-IVD validated product ready for IVDR within timeframes and transition periods specified by the IVDR-2022 regulation
In addition to a Sample Prep Set the products of the Chromatographic Platform are required.


3-Methoxytyramine
Metanephrine
Normetanephrine
MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
With Sample Clean Up Columns, for manual sample prep procedure
Clinical relevance
This Sample Prep Set allows the quantitative determination of total metanephrine, normetanephrine and 3-methoxytyramine in patient urine samples by LC-MS/MS.
One typical application for this kit is the analysis of patient samples with a suspicion of catecholamine-secreting tumours.
Product advantages
- Isotopically labelled internal standard for each analyte
- 6PLUS1® Multilevel Calibrator Set and MassCheck® controls ensure high precision of results
There is also a method using 96 SPE well plates (80700/96) as well as the corresponding automated workflow solution available for laboratories with a higher sample throughput.
This Sample Prep Set encompasses all required components for an efficient sample preparation.
In addition to the Sample Prep Set the products of the Chromatographic Platform are required.
These are the analytical column, mobile phases A and B and the rinsing solution.
Method of Analysis | LC-MS/MS |
---|---|
Number of Tests | 96 |
Please note | The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals. |
Upper Limit of Quantification | Metanephrine, Normetanephrine up to 20 mg/l |
Recovery | 92–107 % |
Intraassay | CV = 2.5–5.6 % |
Interassay | CV = 3.2–4.9 % |
Run Time | 4 min |
Specimen | 24h urine or spontaneous urine |
Pre-analytic Treatment | 24 h urine is collected in a suitable container with 10 ml of 10–25 % HCl. |
Sample Preparation |
|
Sample Stability | Samples are stable for at least 7 days at +2°C to +8°C in amber coloured vials. For longer storage periods keep samples frozen below -18°C. |
Injection Volume | ≤ 20 µl |
Ionisation | ESI positive |
MS/MS Mode | MRM |
Parameter | 3-Methoxytyramine, Metanephrine, Normetanephrine |
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Sample Clean Up Columns Mass Chrom® Biogenic Amines/Metabolites in UrineOrder no.: 80055
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
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Chromatographic Platform Starter SetOrder no.: 80000
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
Identical chromatographic platform for all Sample Prep Sets
Contains analytical column, mobile phases, rinsing solution -
6PLUS1® Multilevel Urine Calibrator Set Total Metanephrines (free + conjugated)Order no.: 80739MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
MassCheck® Total Metanephrines Urine ControlsOrder no.: 0376/0377MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
Tuning Mix MassChrom® Biogenic Amines/MetabolitesOrder no.: 80615
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
-
6PLUS1® Multilevel Urine Calibrator Set Total Metanephrines (free + conjugated)Order no.: 80739MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
MassCheck® Total Metanephrines Urine ControlsOrder no.: 0376/0377MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
In addition to a Sample Prep Set the products of the Chromatographic Platform are required.


3-Methoxytyramine
Metanephrine
Normetanephrine
MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
With Sample Clean Up Columns, for manual sample prep procedure
Clinical relevance
This Sample Prep Set allows the quantitative determination of total metanephrine, normetanephrine and 3-methoxytyramine in patient urine samples by LC-MS/MS.
One typical application for this kit is the analysis of patient samples with a suspicion of catecholamine-secreting tumours.
Product advantages
- Isotopically labelled internal standard for each analyte
- 6PLUS1® Multilevel Calibrator Set and MassCheck® controls ensure high precision of results
There is also a method using 96 SPE well plates (80700/96) as well as the corresponding automated workflow solution available for laboratories with a higher sample throughput.
This Sample Prep Set encompasses all required components for an efficient sample preparation.
In addition to the Sample Prep Set the products of the Chromatographic Platform are required.
These are the analytical column, mobile phases A and B and the rinsing solution.
Method of Analysis | LC-MS/MS |
---|---|
Number of Tests | 96 |
Please note | The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals. |
Upper Limit of Quantification | Metanephrine, Normetanephrine up to 20 mg/l |
Recovery | 92–107 % |
Intraassay | CV = 2.5–5.6 % |
Interassay | CV = 3.2–4.9 % |
Run Time | 4 min |
Specimen | 24h urine or spontaneous urine |
Pre-analytic Treatment | 24 h urine is collected in a suitable container with 10 ml of 10–25 % HCl. |
Sample Preparation |
|
Sample Stability | Samples are stable for at least 7 days at +2°C to +8°C in amber coloured vials. For longer storage periods keep samples frozen below -18°C. |
Injection Volume | ≤ 20 µl |
Ionisation | ESI positive |
MS/MS Mode | MRM |
Parameter | 3-Methoxytyramine, Metanephrine, Normetanephrine |
-
Sample Clean Up Columns Mass Chrom® Biogenic Amines/Metabolites in UrineOrder no.: 80055
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
-
Chromatographic Platform Starter SetOrder no.: 80000
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
Identical chromatographic platform for all Sample Prep Sets
Contains analytical column, mobile phases, rinsing solution -
6PLUS1® Multilevel Urine Calibrator Set Total Metanephrines (free + conjugated)Order no.: 80739MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
MassCheck® Total Metanephrines Urine ControlsOrder no.: 0376/0377MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
Tuning Mix MassChrom® Biogenic Amines/MetabolitesOrder no.: 80615
MassChrom® Biogenic Amines/Metabolites in Urine - LC-MS/MS
-
6PLUS1® Multilevel Urine Calibrator Set Total Metanephrines (free + conjugated)Order no.: 80739MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS
-
MassCheck® Total Metanephrines Urine ControlsOrder no.: 0376/0377MassChrom® Biogenic Amines/Metabolites in Urine – LC-MS/MS