6PLUS1® Multilevel Whole Blood Calibrator Set Immunosuppressants

Order No.: 28039/XL
Cyclosporin A, Everolimus, Sirolimus, Tacrolimus

6PLUS1® Multilevel Whole Blood Calibrator Set Immunosuppressants in whole blood, lyophilised
For MassTox® Immunosuppressants in Whole Blood (93900/400, 93900/1200, 93900/1200/F)

These lyophilised calibrators from Chromsystems are based on human whole blood and should be used according to the instruction manual. They are designed according to the recommendations of the FDA to calibrate the measurement method in clinical diagnostics for the quantitative determination of cyclosporin A, tacrolimus, sirolimus and everolimus in whole blood. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 6 different concentration levels plus 1 blank value.

Please be aware that there are two Multilevel Calibrator Sets available for Immunosuppressants, the standard version and the XL variant. In level 6 of the XL variant the concentration of cyclosporin A is approximately twice as high compared to the standard version (order no. 28039). The concentrations for all other levels are equal.

More Information
Content 7 x 2 ml (lyoph.)

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance UnitCalibrator 1
Calibrator 2
Calibrator 3
Calibrator 4
Calibrator 5
Calibrator 6
Blank Calibrator
Cyclosporin A (Ciclosporin) µg/l 25.3 125 301 476 800 1838 n.d. (< 5)
Tacrolimus (FK 506) µg/l 1.5 5.82 11.9 17.2 24.3 42.3 n.d. (< 0.5)
Rapamycin (Sirolimus) µg/l 2.27 6.46 13.3 19.4 30.4 49.0 n.d. (< 1)
Everolimus µg/l 2.31 6.03 12.2 17.7 25.4 44.5 n.d. (< 1)

 n.d. = not detected (< LOQ)

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1-6. It was not fortified with any immunosuppressants.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored up to 1 week light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 9 months). For more details about storage conditions please check your instruction manual.

Method of Analysis LC-MS/MS
Parameter Cyclosporin A, Everolimus, Sirolimus, Tacrolimus
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