Biogenic Amines
Biogenic amines and their metabolites are important for the diagnosis of a number of diseases such as phaeochromocytoma or other tumours of the nervous system. Reliable results in routine diagnostics are therefore of clinical significance. We offer a range of CE-IVD solutions for HPLC and LC-MS/MS as well as for urine and plasma as matrices. For our LC-MS/MS assays, you may also choose from two different configurations – with 96 SPE well plates or sample clean up columns.
- Assays for HPLC and LC-MS/MS
- CE-IVD validated solutions
- For urine and plasma
Assay Overview
Biogenic Amines in Urine
| Order No. | Chromatographic Platform | Features |
| 80000 |
MassChrom® Biogenic Amines/Metabolites in Urine |
consists of Mobile Phases, Rinsing Solution and Analytical Column |
| Order No. | Sample Prep Sets | Parameters |
| 80600/96 80600/480 |
Catecholamines, free Metanephrines, Serotonin – with 96 SPE Well Plate | Adrenaline Noradrenaline Dopamine Free Metanephrine Free Normetanephrine Free 3-Methoxytyramine Serotonin |
| 80600/C | Catecholamines, free Metanephrines, Serotonin – with Sample Clean Up Columns | |
| 80700/96 | Total Metanephrines (free + conjugated) – with 96 SPE Well Plate | Total Metanephrine Total Normetanephrine Total 3-Methoxytyramine |
| 80700/C | Total Metanephrines (free + conjugated) – with Sample Clean Up Columns | |
| 80800/96 80800/480 |
VMA, HVA, 5-HIAA – with Collection Plates | Vanillylmandelic acid (VMA) Homovanillic acid (HVA) 5-Hydroxyindoleacetic acid (5-HIAA) |
| 80800 | VMA, HVA, 5-HIAA – with Autosampler Vials |
Biogenic Amines in Plasma
| Order No. | Assay | Parameters |
| 81000 | MassChrom® Free Metanephrines in Plasma – with 96 SPE Well Plate | Free Metanephrine Free Normetanephrine Free 3-Methoxytyramine |
| 81000/C | MassChrom® Free Metanephrines in Plasma – with Sample Clean Up Columns |
The LC-MS/MS assays are aimed at the determination of biogenic amines, including solutions for plasma and urine matrices. They are available in 96 SPE well plate format or alternatively with sample clean up columns. Isotope-labelled internal standards for each analyte and 6PLUS1® Multilevel Calibrator Sets as well as MassCheck® controls are also available.
HPLC Assays for Urine
| Order No. | Substance/Group | Parameters | Automation |
| 6000 | Catecholamines | Adrenaline/Epinephrine Noradrenaline/Norepinephrine Dopamine |
Gilson Flexus®/ASPEC® |
| 2020 | Metanephrines | Metanephrines Normetanephrines 3-Methoxytyramine |
Gilson Flexus®/ASPEC® |
| 6000/Combi 2020/Combi |
Catecholamines and Metanephrines | Adrenaline/Epinephrine Noradrenaline/Norepinephrine Dopamine Metanephrines Normetanephrines 3-Methoxytyramine |
|
| 4000 | Serotonin | Serotonin | |
| 1000/B | VMA, HVA, 5-HIAA | Vanillylmandelic acid (VMA) Homovanillic acid (HVA) 5-Hydroxyindoleacetic acid (5-HIAA) |
Gilson Flexus®/ASPEC® |
| 51000 | 5-HIAA | 5-Hydroxyindoleacetic acid (5-HIAA) |
HPLC Assays for Plasma, Serum and Whole Blood
| Order No. | Substance/Group | Parameters | Matrix |
| 5000 | Catecholamines | Adrenaline/Epinephrine Noradrenaline/Norepinephrine Dopamine |
Plasma |
| 3030 | Serotonin | Serotonin | Serum Plasma Whole Blood |
Our HPLC assays allow the determination of biogenic amines, covering solutions for plasma, serum, whole blood and urine matrices.
- CE-IVD validated assays
- Robust assays
- Combined assays for catecholamines and metanephrines
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