Vitamin C

Title Summary Year
Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial Inadequate vitamin C status is related to a low level of mental vitality. Vitamin C supplementation effectively increased work motivation and attentional focus and contributed to better performance on cognitive tasks requiring sustained attention. 2021
Bioavailability of Vitamin C and Folates in Plasma and Its Antioxidant Status after Consumption of Raw and Microwaved BroccolI The raw vegetable consumption produced the highest plasma vitamin C content response, while microwaved samples induced the highest plasma antioxidant status increase. Vitamin C was measured with Chromsystems HPLC assay. 2021
Systemic Catecholaminergic Deficiency in Depressed Patients with and without Coronary Artery Disease The main results that they found in the study are reduced circulating epinephrine and dopamine levels in depression, regardless of the coronary artery disease status. 2021
Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors This study provides preliminary evidence for the use of GSH precursors combined with polydatin to maintain redox status into an ideal range. Chromsystems assays were used for the determination of vitamin A/E/C 2020
Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation The results of this study suggest that magnesium supplementation enhanced the anticancer effect of AA by inhibiting the hormetic response at a low dose. This study has also demonstrated that AA treatment with magnesium supplementation provided more effective anticancer therapy than AA treatment alone. Measured with Chromsystems assay by HPLC.  2020
Plasma Vitamin C Concentrations and Cognitive Function: A Cross-Sectional Study In conclusion there was a significant association between vitamin-C plasma concentrations and performance on tasks involving attention, focus, working memory, decision speed, delayed and total recall, and recognition.  Vitamin C in this study was measured by the Chromsystems assay. 2019
Hyperphenylalaninemia Correlated with Global Decrease of Antioxidant Genes Expression in White Blood Cells of Adult Patients with Phenylketonuria This study is the first to evaluate the expression of 22 antioxidant genes in white blood cells regarding biochemical parameters in PKU. Vitamin A, C and E measured with Chromsystems assays. 2017
Impact of oral vitamin C on histamine levels and seasickness vitamin C is effective in suppressing symptoms of seasickness, particularly in women and men younger than 27 years of age, and is devoid of side effects. Histamine levels were initially increased after the test persons had been exposed to waves. Vitamin C was measured with the Chromsystems assay. 2014
Antioxidant defense and oxidative stress in children with acute hepatitis A Their research points out that hepatatis A infection causes oxidative stress in children. Antioxidant vitamin supplements could be added to the therapy for these patients to help reestablish the oxidant status balance. However, further investigations to confirm this suggestion are recommended. Ascorbic acid, α-tocopherol, retinol, β-carotene, and GSH, Malondialdehyde measured with Chromsystems assay. 2011


Title Summary Year
A Stabilizing Agent, PCA/DTPA, Improves Plasma Storage Life for the Chromsystems Vitamin C Assay up to Six Months PCA/DTPA significantly reduces ascorbate oxidation, and PCA/DTPA-stabilized ascorbate plasma is compatible with the Chromsystems assay and stable for up to six months, when stored at -80°C. 2021
Vitamin C Measurement in Critical Illness: Challenges, Methodologies and Quality Improvements Current analytical performance of vitamin C HPLC methodologies are acceptable for the requirements of a high-dose vitamin C RCTs. Recommendations across the total testing process of vitamin C have been provided to improve the quality of the results. The harmonisation of sample handling and processing procedures will further improve the reliability of current analytical methodologies.  2020


Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements. 

Title Summary Year
Gressner A.M., Arndt T. (Eds). Lexikon der Medizinischen Laboratoriumsdiagnostik, 3rd edition, Springer Verlag (2019).   Book with reference values.  2019
Ascorbic Acid Determination With an Automated Enzymatic Procedure Provides reference values with an old-fashioned method 1997