Malondialdehyde

Title Summary Year
Effect of a New Formulation of Nutraceuticals as an Add-On to Metformin Monotherapy for Patients with Type 2 Diabetes and Suboptimal Glycemic Control: A Randomized Controlled Trial In patients with type 2 diabetes taking metformin with suboptimal glycemic compensation, adding BHC for 3 months significantly improved glucose control and had a positive effect on the lipid peroxidation profile, as indicated by a decrease in MDA, the latter measured by Chromsystems HPLC assay. 2021
Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress Results suggest that in elderly patients with advanced CKD, the gMB composition is significantly different between sarcopenic and not-sarcopenic individuals. Furthermore, in patients with chronic kidney disease, there are many mutual correlations between gut microbiota composition, uremic toxins, inflammatory cytokines and oxidative stress parameters.MDA measured with Chromsystems HPLC assay. 2021
Lycopene minimizes skin toxicity and oxidative stress in patients treated with panitumumab-containing therapy for metastatic colorectal cancer The study shows an absolute reduction of skin grade 2–3 toxicity. Lactolycopene administration was able to abolish malondialdehyde (MDA) production, a biomarker used to measure lipid peroxidation in the organism, and replenish antioxidant consumption in the course of anti-EGFR therapy. MDA was measured with Chromsystems assay. 2021
Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial First study addressing the role of melatonin in very low birth weight preterm newborns, that could provide a basis for further studies on melatonin as a neuroprotection strategy in this vulnerable population. MDA measured with Chromsystems HPLC assay. 2021
Changes in Oxidative Stress, Inflammation, andMuscle Damage Markers Following Diet andBeetroot Juice Supplementation in Elite Fencers we showed that long-term beetroot juice supplementation increases lipid peroxidation, and improvement of VO2max after ID&BEET seems to be dependent on LDH activity, as well as on the serum concentration of MDA and β-carotene. MDA was measured by HPLC with the Chromsystems assay. 2020
Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers. A study of the Spanish CoRIS cohort, 2004-2015 Vascular events in PLWH do preferentially occur in the older age-strata, they are associated with increased mortality and, compared to the general population, the excess risk occurs at younger ages. 2019
Impact of Alpha-Lipoic Acid Chronic DiscontinuousTreatment in Cardiometabolic Disorders andOxidative Stress Induced by Fructose Intake in Rats  Our study supports the promising potential of the chronic-discontinuous treatment of alpha-lipoic acid  and highlights the pleiotropic effects of this antioxidant substance in metabolic
disorders, such as diabetes mellitus. MDA was measured by Chromsystems assay.
2019
The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q10 Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study The findings of this study imply that the combination of ALA and CoQ10 has beneficial effects on oxidative stress induced by ischemia-reperfusion injury. GSH and MDA measured by Chromsystems assay. 2016
A Nitric Oxide-Donor Furoxan Moiety Improves the Efficacy of Edaravone Against Early Renal Dysfunction and Injury Evoked by ischemia/reperfusion Overall, these findings demonstrate that the NO-donor moiety contributes to the protection against early renal I/R injury. MDA measured by Chromsystems assay.  2015
Comparison of Airway and Systemic Malondialdehyde Levels for Assessment of Oxidative Stress in Cystic Fibrosis MDA is a potential new airway marker of oxidative stress in patients with CF. Sputum MDA differentiates best between patients and healthy subjects, which was measured by Chromsystems assay. 2015
Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment The present data suggest the presence of several processes which contribute and possibly interact to impair liver functions in type 1 diabetes, several of which are potentially amenable to therapeutic interventions with resveratrol. MDA and GSH measured with Chromsystems assay. 2015
Oxidative Stress in Algerian Adults Obesity The decrease in antioxidant defenses and increased lipid peroxidation in obese subjects reflect a profound oxidative stress, which would be one of the mechanisms involved in the onset of diseases caused by the obesity. Mda measured by Chromsystems HPLC assay. 2015
Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients In virologically suppressed HIV-infected patients, coinfection with HHV-8 is associated with increased inflammation and immune activation.  MDA measured by Chromsystems. Assay 2014
Improvement of Oxidative and Metabolic Parameters by Cellfood Administration in Patients Affected by Neurodegenerative Diseases on Chelation Treatment Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects' metabolic conditions. GSH and MDA measured by Chromsystems assay. 2014
Lung matrix metalloproteinase activation following partial hepatic ischemia/reperfusion injury in rats First study in which the matrix metalloproteinases activation in a distant organ is reported; MDA measured with Chromsystems assay.  2014
Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde MDA in sputum, but not in EBC, appears to be a useful marker for monitoring exacerbation-associated oxidative stress in AECOPD. MDA was measured by Chromsystems assay.  2014
Oxidative stress in kidney transplantation: malondialdehyde is an early predictive marker of graft dysfunction  Increased MDA levels on day 1 after KTx might be an early prognostic indicator of DGF, and levels on day 7 might represent a useful predictor of 1-year graft function. MDA measured with Chromsystems assay.  2014
Increased Carotid Intima-Media Thickness Associated With Antibody Responses to Varicella-Zoster Virus and Cytomegalovirus in HIV-infected Patients In virologically suppressed HIV-infected patients, antibody responses against herpesviruses are associated with subclinical atherosclerosis, and with increased inflammation and coagulation biomarkers. Mda measured with Chromsystems assay. 2013
Iron metabolism is associated with adipocyte insulin resistance and plasma adiponectin: the Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) study The observed associations of several markers of iron metabolism with adipocyte IR and adiponectin suggest that factors related to iron and iron metabolism may contribute to adipocyte IR early in the pathogenesis of T2DM. MDA measured with Chromsystems assay.  2013
Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial Overall, add-on Eicosapentaenoic acid supplementation has limited effects on biological risk factors for adverse outcome in this sample of diabetes patients with comorbid major depression. MDA measured with Chromsystems assay.  2012
Plasma Soluble α-klotho Protein Levels in Premature and Term Neonates: Correlations With Growth and Metabolic Parameters Soluble α-KL levels rise as gestational age and postnatal age advance in neonates and may have an impact on vitamin D metabolism and oxidative stress. Mda was measured by the Chromsystems assay.  2012
Evaluation of Oxidative Stress Markers in First Trimester for Assessment of Preeclampsia Risk  A panel of oxidative stress markers such as MDA and PGF(2α) in maternal blood can predict the development of preeclampsia long before clinical onset. Measured with the Chromsystems assay for MDA.  2011
Antioxidant defense and oxidative stress in children with acute hepatitis A Their research points out that hepatatis A infection causes oxidative stress in children. Antioxidant vitamin supplements could be added to the therapy for these patients to help reestablish the oxidant status balance. However, further investigations to confirm this suggestion are recommended. Ascorbic acid, α-tocopherol, retinol, β-carotene, and GSH, Malondialdehyde measured with Chromsystems assay . 2011

Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements. 

Title Summary Year
Comparison of different assays for malondialdehyde using thiobarbituric acid This study compares different assays for malondialdehyde using thiobarbituric acid, and provide suggestions for reference values of MDA.  1992