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3PLUS1® Multilevel Plasma Calibrator Set Antiepileptic Drugs/EXTENDED

Order No.: 92025/XT
Parameters:
10,11-Dihydroxycarbamazepine, 10-OH-Carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic Acid, Vigabatrin, Zonisamide
MassTox® TDM Series A Antiepileptic Drugs in Serum/Plasma – LC-MS/MS
main product photo

Brivaracetam

Carbamazepine

Carbamazepine-10,11-epoxide

10,11-Dihydroxycarbamazepine

10-OH-Carbamazepine

Oxcarbamazepine

Ethosuximide

Felbamate

Gabapentin

Lacosamide

Lamotrigine

Levetiracetam (Keppra®)

N-Desmethylmesuximide

Perampanel

Phenobarbital

Phenylethylmalonamide (PEMA)

Phenytoin

Pregabalin

Primidone

Retigabine

Rufinamide

Stiripentol

Sultiame

Theophylline

Tiagabine

Topiramate

Valproic acid

Vigabatrin

Zonisamide

3PLUS1® Multilevel Plasma Calibrator Set Antiepileptic Drugs/EXTENDED, lyophilised

For MassTox® TDM Series A Parameter Sets by LC-MS/MS:
Antiepileptic Drugs in Serum/Plasma (92921)
Antiepileptic Drugs All-in-One-Methode in Serum/Plasma (92921/XT)

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of antiepileptic drugs in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

More Information
Content 4 x 1 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

NEW: An Excel file with the data from the product information leaflet is now available in the "Downloads" section (for registered customers only). This eliminates manual data entry of large data sets.

Substance

Calibrator 1

(mg/l)

Calibrator 2

(mg/l)

Calibrator 3

(mg/l)

Blank Calibrator

(mg/l)

10-OH-Carbamazepine

3.43

25.1

45.7

n.d. (<0.500)

Carbamazepine

1.62

8.35

14.0

n.d. (<0.371)

Carbamazepine-10.11-epoxide

0.158

5.64

10.3

n.d. (<0.021)

Carbamazepine-Diol

0.137

5.60

12.2

n.d. (<0.052)

Oxcarbazepine

0.137

1.83

3.60

n.d. (<0.020)

Felbamate

12.9

68.1

121

n.d. (<1.100)

Lacosamide

0.735

6.25

11.2

n.d. (<0.092)

Lamotrigine

1.51

9.66

17.0

n.d. (<0.192)

Levetiracetam

5.06

30.5

100.2

n.d. (<0.750)

Rufinamide

3.99

20.5

34.1

n.d. (<0.506)

Theophylline

6.22

15.7

24.7

n.d. (<1.01)

Gabapentin

1.58

14.5

25.5

n.d. (<0.315)

Pregabalin

0.146

6.35

12.2

n.d. (<0.025)

Sultiame

0.371

8.10

15.0

n.d. (<0.075)

Tiagabine (in µg/l)

13.5

126

230

n.d. (<2.00)

Topiramate

0.642

15.6

29.4

n.d. (<0.191)

Vigabatrin

1.48

22.7

41.2

n.d. (<0.297)

N-Desmethylmesuximide

6.99

27.5

47.3

n.d. (<1.42)

PEMA

0.997

6.31

11.2

n.d. (<0.149)

Phenytoin

3.45

13.9

23.4

n.d. (<0.715)

Primidone

3.06

11.4

18.7

n.d. (<0.502)

Stiripentol

2.80

14.4

24.1

n.d. (<0.413)

Ethosuximide

20.3

66.4

110

n.d. (<6.11)

Phenobarbital

6.34

30.8

55.1

n.d. (<0.925)

Valproic acid

28.4

73.4

120

n.d. (<8.83)

Zonisamide

3.73

27.6

49.1

n.d. (<1.43)

Brivaracetam

0.618

2.42

4.19

n.d. (<0.074)

Perampanel (in µg/l)

35.7

1003

1780

n.d. (<20.0)

Retigabine (in µg/l)

48.7

1058

2050

n.d. (<28.0)

n.d. = not determined, analytes under LOQ

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any antiepileptic drugs.
Method of Analysis LC-MS/MS
Parameters 10,11-Dihydroxycarbamazepine, 10-OH-Carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic Acid, Vigabatrin, Zonisamide

Download of Product Information Leaflets
For logged-in customers the product information leaflets for calibrators, controls, internal standards and tuning mixes can be downloaded from the downloadcenter.

Download of all other documents
In the below section logged-in customers can download various documents such as instruction manuals, safety data sheets, traceability chains for calibrators, and external quality assessments.
These documents can also be downloaded from the downloadcenter.

As a customer please login or register to gain full access.

Brivaracetam

Carbamazepine

Carbamazepine-10,11-epoxide

10,11-Dihydroxycarbamazepine

10-OH-Carbamazepine

Oxcarbamazepine

Ethosuximide

Felbamate

Gabapentin

Lacosamide

Lamotrigine

Levetiracetam (Keppra®)

N-Desmethylmesuximide

Perampanel

Phenobarbital

Phenylethylmalonamide (PEMA)

Phenytoin

Pregabalin

Primidone

Retigabine

Rufinamide

Stiripentol

Sultiame

Theophylline

Tiagabine

Topiramate

Valproic acid

Vigabatrin

Zonisamide

3PLUS1® Multilevel Plasma Calibrator Set Antiepileptic Drugs/EXTENDED, lyophilised

For MassTox® TDM Series A Parameter Sets by LC-MS/MS:
Antiepileptic Drugs in Serum/Plasma (92921)
Antiepileptic Drugs All-in-One-Methode in Serum/Plasma (92921/XT)

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method in clinical diagnostics for the quantitative determination of antiepileptic drugs in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

More Information
Content 4 x 1 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

NEW: An Excel file with the data from the product information leaflet is now available in the "Downloads" section (for registered customers only). This eliminates manual data entry of large data sets.

Substance

Calibrator 1

(mg/l)

Calibrator 2

(mg/l)

Calibrator 3

(mg/l)

Blank Calibrator

(mg/l)

10-OH-Carbamazepine

3.43

25.1

45.7

n.d. (<0.500)

Carbamazepine

1.62

8.35

14.0

n.d. (<0.371)

Carbamazepine-10.11-epoxide

0.158

5.64

10.3

n.d. (<0.021)

Carbamazepine-Diol

0.137

5.60

12.2

n.d. (<0.052)

Oxcarbazepine

0.137

1.83

3.60

n.d. (<0.020)

Felbamate

12.9

68.1

121

n.d. (<1.100)

Lacosamide

0.735

6.25

11.2

n.d. (<0.092)

Lamotrigine

1.51

9.66

17.0

n.d. (<0.192)

Levetiracetam

5.06

30.5

100.2

n.d. (<0.750)

Rufinamide

3.99

20.5

34.1

n.d. (<0.506)

Theophylline

6.22

15.7

24.7

n.d. (<1.01)

Gabapentin

1.58

14.5

25.5

n.d. (<0.315)

Pregabalin

0.146

6.35

12.2

n.d. (<0.025)

Sultiame

0.371

8.10

15.0

n.d. (<0.075)

Tiagabine (in µg/l)

13.5

126

230

n.d. (<2.00)

Topiramate

0.642

15.6

29.4

n.d. (<0.191)

Vigabatrin

1.48

22.7

41.2

n.d. (<0.297)

N-Desmethylmesuximide

6.99

27.5

47.3

n.d. (<1.42)

PEMA

0.997

6.31

11.2

n.d. (<0.149)

Phenytoin

3.45

13.9

23.4

n.d. (<0.715)

Primidone

3.06

11.4

18.7

n.d. (<0.502)

Stiripentol

2.80

14.4

24.1

n.d. (<0.413)

Ethosuximide

20.3

66.4

110

n.d. (<6.11)

Phenobarbital

6.34

30.8

55.1

n.d. (<0.925)

Valproic acid

28.4

73.4

120

n.d. (<8.83)

Zonisamide

3.73

27.6

49.1

n.d. (<1.43)

Brivaracetam

0.618

2.42

4.19

n.d. (<0.074)

Perampanel (in µg/l)

35.7

1003

1780

n.d. (<20.0)

Retigabine (in µg/l)

48.7

1058

2050

n.d. (<28.0)

n.d. = not determined, analytes under LOQ

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any antiepileptic drugs.
Method of Analysis LC-MS/MS
Parameters 10,11-Dihydroxycarbamazepine, 10-OH-Carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic Acid, Vigabatrin, Zonisamide

Download of Product Information Leaflets
For logged-in customers the product information leaflets for calibrators, controls, internal standards and tuning mixes can be downloaded from the downloadcenter.

Download of all other documents
In the below section logged-in customers can download various documents such as instruction manuals, safety data sheets, traceability chains for calibrators, and external quality assessments.
These documents can also be downloaded from the downloadcenter.

As a customer please login or register to gain full access.