6PLUS1® Multilevel Whole Blood Calibrator Set Immunosuppressants

Order No.: 28039
Parameters:
Cyclosporin A, Everolimus, Sirolimus, Tacrolimus

MassTox® Immunosuppressants in Whole Blood - LC-MS/MS

6PLUS1® Multilevel Calibrator Whole Blood Set Immunosuppressants, lyophilised

These lyophilised calibrators from Chromsystems are based on human whole blood and should be used according to the instruction manual. They are designed according to the recommendations of the FDA to calibrate the measurement method in clinical diagnostics for the quantitative determination of cyclosporin A, tacrolimus, sirolimus and everolimus in whole blood. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 6 different concentration levels plus 1 blank value.

More Information
Content 7 x 2 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance UnitCalibrator 1
(28031)
Calibrator 2
(28032)
Calibrator 3
(28033)
Calibrator 4
(28034)
Calibrator 5
(28035)
Calibrator 6
(28036)
Blank Calibrator
(28030)
Cyclosporin A (Ciclosporin) µg/l 25.3 125 301 476 800 971 n.d. (< 10)
Tacrolimus (FK 506) µg/l 1.5 5.82 11.9 17.2 24.3 41.6 n.d. (< 0.5)
Rapamycin (Sirolimus) µg/l 2.27 6.46 13.3 19.4 30.4 49.6 n.d. (< 1)
Everolimus µg/l 2.31 6.03 12.2 17.7 25.4 44.1 n.d. (< 1)

 n.d. = not detected (< LOQ)

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1-6. It was not fortified with any immunosuppressants.

Reconstitution

Carefully remove the metal seal and rubber stopper from the vials. Add exactly 2.0 ml of distilled water into each vial. Return the stopper and incubate for 10 to 15 minutes at room temperature. Swirl the vials to dissolve the contents until homogeneity.

Storage conditions

Stored below -18 °C and unopened, the lyophilised calibrators are stable until the expiry date specified on the vial labels. The reconstituted calibrators can be stored up to 1 week light protected and tightly capped at +2 to +8 C. If the calibrators cannot be used within this period, they should be aliquoted and stored frozen below -18 °C (up to 9 months). For more details about storage conditions please check your instruction manual.

Method of Analysis LC-MS/MS
Parameter Cyclosporin A, Everolimus, Sirolimus, Tacrolimus
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