MassScreen® Amino Acids, Acylcarnitines EXTENDED from Dried Blood
The new extended assays allow the simultaneous determination of 62 analytes, thereby increasing the number of metabolic diseases that can be screened for in a single run.
Validated in accordance with IVDR, the assays meet stringent regulatory requirements. A comprehensive panel of internal standards is designed to support precise and consistent measurements. The upper end of the measuring range of the MS/MS system can be determined using the new linearity sets. In addition, the newly introduced three-point controls are developed to support precision and reproducibility.
- 62 analytes in one run, including adenosine and 2'-deoxyadenosine
- IVDR certified
- No derivatisation required
- No analytical column necessary
- Matrix-based controls at three concentration levels
- Linearity sets for determining the upper end of the MS/MS measuring
range
Parameter menu
Amino acids
Alanine / sarcosine*
Arginine
Argininosuccinic acid
Citrulline
Glutamine / lysine*
Glutamic acid
Glycine
Leucine / isoleucine / allo-isoleucine / hydroxyproline*
Methionine
Ornithine
Phenylalanine
Proline
Serine
Tyrosine
Valine
3-O-Methyldopa
Nucleosides
Adenosine**
2‘-Deoxyadenosine**
Ketone
Succinylacetone
Creatine and related metabolites
Creatine
Creatinine
Guanidinoacetic acid
Lysophospholipids
C20:0 LPC 1-Arachidoyl-2-hydroxy-sn-glycero-3-phosphocholine
C22:0 LPC 1-Behenoyl-2-hydroxy-sn-glycero-3-phosphocholine
C24:0 LPC 1-Lignoceroyl-2-hydroxy-sn-glycero-3-phosphocholine
C26:0 LPC 1-Hexacosanoyl-2-hydroxy-sn-glycero-3-phosphocholine
Carnitines
C0 Free carnitine
C2 Acetylcarnitine
C3 Propionylcarnitine
C3DC / C4OH Malonylcarnitine (C3DC) /
3-hydroxybutyrylcarnitine /
3-hydroxyisobutyrylcarnitine (C4OH)*
C4 Butyrylcarnitine / isobutyrylcarnitine*
C4DC / C5OH Methylmalonylcarnitine /
succinylcarnitine (C4DC) / 3-hydroxyisovalerylcarnitine / 2-methyl-3-hydroxybutyrylcarnitine (C5OH)*
C5 Isovalerylcarnitine / 2-methylbutyrylcarnitine*
C5:1 Tiglylcarnitine / 3-methylcrotonylcarnitine
C5DC / C6OH Glutarylcarnitine (C5DC) /
3-hydroxyhexanoylcarnitine (C6OH)*
C6 Hexanoylcarnitine
C6DC Adipylcarnitine / 3-methylglutarylcarnitine*
C8 Octanoylcarnitine
C8:1 Octenoylcarnitine
C10 Decanoylcarnitine
C10:1 Decenoylcarnitine
C10:2 Decadienoylcarnitine
C12 Dodecanoylcarnitine
C12:1 Dodecenoylcarnitine
C14 Tetradecanoylcarnitine
C14:1 Tetradecenoylcarnitine
C14:2 Tetradecadienoylcarnitine
C14OH 3-Hydroxytetradecanoylcarnitine
C16 Hexadecanoylcarnitine
C16:1 Hexadecenoylcarnitine
C16OH 3-Hydroxyhexadecanoylcarnitine
C16:1OH / C17 3-Hydroxyhexadecenoylcarnitine (C16:1OH) / heptadecanoylcarnitine (C17)*
C18 Octadecanoylcarnitine
C18:1 Octadecenoylcarnitine
C18:2 Octadecadienoylcarnitine
C18OH 3-Hydroxyoctadecanoylcarnitine
C18:1OH 3-Hydroxyoctadecenoylcarnitine
C18:2OH 3-Hydroxyoctadecadienoylcarnitine
C20 Eicosanoylcarnitine
C22 Docosanoylcarnitine
C24 Tetracosanoylcarnitine
C26 Hexacosanoylcarnitine
* Isomers and isobars cannot be differentiated with these assays.
** With the MassScreen® Kits 57075-ADO and 57075-F-ADO
Sample preparation
The samples are prepared based on the effective extraction of the analytes from the dried blood spot. In the version with 96 well filter plates, a transfer step to a new plate is replaced with a centrifugation step, simplifying one step of the process.
MassScreen® Kits
There are two kit options available with or without adenosine (Ado) / 2‘-deoxyadenosine (dAdo) measurement. Each of these options are available in two versions with 96 well plates or 96 well filter plates. The kits contain all of the reagents and vials required for sample preparation as well as the mobile phase, internal standards and controls. There are two versions to ensure the optimal adaptation to different laboratory requirements:
- With 96 Well Plates: the samples are transferred by pipetting
- With 96 Well Filter Plates: the samples are transferred efficiently through centrifugation
Bestell-Nr.
Produkt
Linearity Sets
The Chromsystems Multilevel Dried Blood Spot Linearity Sets are used to determine the upper end of the MS/MS system’s linear dynamic range. They are applied to filter paper and are prepared and measured in the same way as patient samples. The linearity sets are available in two versions, with and without Ado/dAdo and are based on human whole blood.
- Based on human matrix material (whole blood)
- On filter paper
- Set available with and without Ado/dAdo
- Schedule a personalised consultation tailored to your lab’s needs
- Place an order and discuss availability
- Learn how the MassScreen® Amino Acids, Acylcarnitines EXTENDED from Dried Blood Assay can be integrated into your workflow
Don’t miss the opportunity to upgrade your newborn screening capabilities with a fully IVDR-compliant and efficient solution.
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