Immunosuppressants

Title Summary Year
A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance This study determined the drug interaction potential of clementines. Tacrolimus was measured with MassTox Immunosuppressants 2019
Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers The aim of the study was to investigate the effects of the potent P‐gp inhibitor ciclosporin and its combination with the moderate CYP3A inhibitor fluconazole on rivaroxaban pharmacokinetics and on CYP3A activity. Study used MassTox Immunosuppressants for ciclosporine analysis. 2019
First Report of a Successful Pregnancy in an Everolimus‐Treated Heart‐Transplanted Patient: Neonatal Disappearance of Immunosuppressive Drugs The paper reports a successful Pregnancy in an Everolimus-Treated Heart-Transplanted Patient. The concentration of everolimus was measured with MassTox Immunosuppressants 2016
Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation. Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important, that has been performed with MassTox Immunosuppressants assay.  2015
Title Summary Year
Immunosuppressive drugs in whole blood: validation of a commercially available liquid chromatography/tandem mass spectrometry kit and comparison with immunochemical assays The  comparison of patient data between LC/MS/MS and up‐dated immunoassays shows that a significant discrepancy still exists, especially for CSA and SIRO, confirming the greater specificity associated with use of the LC/MS/MS, measured with the OneMinute assay from Chromsystems 2017
Immunosuppressive drugs in whole blood: validation of a commercially available liquid chromatography/tandem mass spectrometry kit and comparison with immunochemical assays. The evaluation of MassTox Immunosuppressants in comparison with immunoassays confirms greater specificty associated with use of LC-MS/MS assay 2017
Comparison between ultra-performance liquid chromatography with tandem mass spectrometry and a chemiluminescence immunoassay in the determination of cyclosporin A and tacrolimus levels in whole blood. LC-M/MS of immunosuppressants, here performed with the Chromsystems assay, is superior to an immunoassay 2013
Evaluation of a novel commercial assay for the determination of cyclosporine A, tacrolimus, sirolimus, and everolimus by liquid chromatography-tandem mass spectrometric assay. The commercial immunosuppressant assay from Chromsystems represents a standardized IVD-certified alternative to our in-house developed assay.  2013
Instrument-specific Matrix Effects of Calibration Materials in the LC-MS/MS Analysis of Tacrolimus isotpocailly labelled internal standards are important acording to this letter to the editor.  2008
Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. The sample prep of Chromsystems yields considerable cleaner extracts for cyclosporine in comparison to an in-house method 1992

Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements. 

Title Summary Year
Gressner A.M., Arndt T. (Eds). Lexikon der Medizinischen Laboratoriumsdiagnostik, 3rd edition, Springer Verlag (2019).   Book with reference values 2019
Immunosuppressive drugs in whole blood: validation of a commercially available liquid chromatography/tandem mass spectrometry kit and comparison with immunochemical assays. The evulation of MassTox Immunosuppressants in comparison with immunoassays confirms greater specificty associated with use of LC-MS/MS assay 2017
Thomas L. (ed)- Labor und Diagnose, 8th edition, TH books (2012) Book with reference values 2012