Glutathione (GSH)

Title Summary Year
The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

The study confirms a protective effect of olive oil in parenteral nutrition mixtures containing omega-3 polyunsaturated fatty acids. GSH was measured with the Chromsystems assay. 2020
Anticataractogenic effect of betaine in chick embryo hydrocortisone-induced cataract model Administration of a dose of 0.25 μmol/egg betaine showed a significant anti-cataract effect in chick embryo SIC model. This finding is significant as it shows betaine as a potential anti-oxidant agent preventing cataract formation. HPLC assay used for GSH 2019
Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome  As well as ameliorating oxidative stress, Troxerutin can reduce ectopic lipid deposition, affect genes involved in lipid metabolism, and influence the activity of CYP family enzymes. 2019
Effect of Short-Term Dietary Intervention and Probiotic Mix Supplementation on the Gut Microbiota of Elderly Obese Women  These findings support the relevant role of a correct dietetic approach, even in the short term, to modulate the EO gut microbiota towards a metabolic health-related configuration, counteracting the increased risk of morbidity in these patients. 2019
Effect of Short-Term Dietary Intervention and
Probiotic Mix Supplementation on the Gut
Microbiota of Elderly Obese Women
 These findings support the relevant role of a correct dietetic approach, even in the short term, to modulate the EO gut microbiota towards a metabolic health-related configuration, counteracting the increased risk of morbidity in these patients.. GSH, GSSG and MDA were determined by high-performance liquid chromatography (HPLC) using kits from Chromsystems.  2019
The Protective Effects of Alpha-Lipoic Acid and Coenzyme Q10 Combination on Ovarian Ischemia-Reperfusion Injury: An Experimental Study The findings of this study imply that the combination of ALA and CoQ10 has beneficial effects on oxidative stress induced by ischemia-reperfusion injury. GSH and MDA measured by Chromsystems assay 2016
Combined Intervention With Pioglitazone and n-3 Fatty Acids in Metformin-Treated Type 2 Diabetic Patients: Improvement of Lipid Metabolism Thus, typical T2D patients may be advised to increase their EPA + DHA intake, either in the form of dietary supplements or sea food and fish, in order to increase the efficacy of pharmacotherapies and to prevent diseases linked to inflammation as well as cardiovascular disease, providing that glycemic control is closely monitored. EPA + DHA are likely to bring benefits on cardiovascular health of diabetic patients. GSH measured with Chromsystems assay. 2015
Differential Gene Expression in Liver Tissues of Streptozotocin-Induced Diabetic Rats in Response to Resveratrol Treatment The present data suggest the presence of several processes which contribute and possibly interact to impair liver functions in type 1 diabetes, several of which are potentially amenable to therapeutic interventions with resveratrol. GSH was measured with Chromsystems assay. 2015
Differential gene expression in liver tissues of streptozotocin-induced diabetic rats in response to resveratrol treatment The present data suggest the presence of several processes which contribute and possibly interact to impair liver functions in type 1 diabetes, several of which are potentially amenable to therapeutic interventions with resveratrol. MDA and GSH measured with Chromsystems assay. 2015
Differential Acute Postprandial Effects of Processed Meat and Isocaloric Vegan Meals on the Gastrointestinal Hormone Response in Subjects Suffering From Type 2 Diabetes and Healthy Controls: A Randomized Crossover Study Our results suggest that the diet composition and the energy content, rather than the carbohydrate count, should be important considerations for dietary management and demonstrate that processed meat consumption is accompanied by impaired GIH responses and increased oxidative stress marker levels in diabetic patients. GSH measured with Chromsystems assay. 2014
Improvement of Oxidative and Metabolic Parameters by Cellfood Administration in Patients Affected by Neurodegenerative Diseases on Chelation Treatment Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects' metabolic conditions. GSH measured by Chromsystems assay. 2014
Postprandial Oxidative Stress and Gastrointestinal Hormones: Is There a Link? The study found no direct link between gastrointestinal hormones and oxidative stress markers in diabetic patients. GSH measured with Chromsystems assay. 2014
Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats The results are consistent with the hypothesis that folate deficiency can promote oxidative stress and multiple features of the metabolic syndrome that are associated with increased risk for diabetes and cardiovascular disease. GSH measured with Chromsystems assay.  2013
Antioxidant defense and oxidative stress in children with acute hepatitis A Their research points out that hepatatis A infection causes oxidative stress in children. Antioxidant vitamin supplements could be added to the therapy for these patients to help reestablish the oxidant status balance. However, further investigations to confirm this suggestion are recommended. Ascorbic acid, α-tocopherol, retinol, β-carotene, and GSH, Malondialdehyde measured with Chromsystems assay . 2011
Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats The increase of antioxidant status (TAS)  could represent one of the possible mechanism through which the US therapy exerts its favorable
effects in OA. Further studies will be required to investigate the biochemical nature of TAS increase.
2011
Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes A calorie-restricted vegetarian diet had greater capacity to improve insulin sensitivity compared with a conventional diabetic diet over 24 weeks. The greater loss of visceral fat and improvements in plasma concentrations of adipokines and oxidative stress markers with this diet may be responsible for the reduction of insulin resistance. The addition of exercise training further augmented the improved outcomes with the vegetarian diet. Shorteing. GSH was measured by Chromsystems assay.  2011
Vegetarian Diet Improves Insulin Resistance and Oxidative Stress Markers More Than Conventional Diet in Subjects With Type 2 Diabetes A calorie-restricted vegetarian diet had greater capacity to improve insulin sensitivity compared with a conventional diabetic diet over 24 weeks. The greater loss of visceral fat and improvements in plasma concentrations of adipokines and oxidative stress markers with this diet may be responsible for the reduction of insulin resistance. MDA measured with Chromsystems assay 2011
Antioxidant defense and oxidative stress in children with acute hepatitis A The findings show that pediatric patients with acute hepatitis A were influenced by oxidative stress, resulting in significantly lower levels of plasma antioxidants and increased lipid peroxidation. ascorbic acid, α-tocopherol, retinol, β-carotene, and GSH in whole blood were measured by Chromsystems assays.  2011

Please find here publications as guides for reference ranges or therapeutic ranges. As they may differ from other published data. Data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements. 

Title Summary Year
Blood Glutathione Disulfide: In Vivo Factor or in Vitro Artifact? GSSG is present in healthy human blood at low concentrations (2-6 micromol/L), and most published data on GSSG may be affected by artifacts, according to this study.  2002
Quantification of Reduced and Oxidized Glutathione in Whole Blood Samples by Capillary Electrophoresis This study quantiified reduced and oxidised glutathione in whole blood samples.  2001
Glutathione deficiency is associated with impaired survival in HIV disease The study argues that GSH deficiency may be a a key determinant of survival in HIV disease.  1997