MassTox® Drugs of Abuse Testing
The powerful assay enables the simultaneous quantitative determination of 108 drugs and metabolites in a single run, offering a broad spectrum for urine diagnostics.
All analytes are validated in compliance
with IVDR and meet the relevant regulatory requirements.
- 108 analytes quantitatively determined in a single run
- All analytes validated in compliance with IVDR
- Hydrolysis in just 30 minutes
- Hydrolysis efficiency monitoring in every single patient sample
- Simple hydrolysis at room temperature without a water bath
Parameter Menu
Amphetamines
Amphetamine
BDB
Butylone
2C-B
2C-I
Cathinone
MBDB
MDA
MDEA
MDMA
MDPV
Mephedrone
Methamphetamine
Methaqualone
Methylone
Methylphenidate
PMA
Ritalinic acid
Barbiturates
Allobarbital
Amobarbital
Barbital
Butalbital
Hexobarbital
Pentobarbital
Phenobarbital
Secbutabarbital
Secobarbital
Thiopental
Boosters
Gabapentin
Pregabalin
Promethazine
Quetiapine
Z-drugs
Zaleplon
Zolpidem
Zopiclone
Benzodiazepines
Alprazolam
7-Aminoclonazepam
7-Aminoflunitrazepam
7-Aminonitrazepam
Bromazepam
Brotizolam
Chlordiazepoxide
Clobazam
Clonazepam
Demoxepam
Desalkylflurazepam
Desmethylflunitrazepam
Diazepam
Estazolam
Flunitrazepam
Flurazepam
α-OH-Alprazolam
α-OH-Midazolam
α-OH-Triazolam
3-Hydroxybromazepam
Lorazepam
Lormetazepam
Medazepam
Midazolam
Nitrazepam
Norclobazam
Nordiazepam
Oxazepam
Prazepam
Temazepam
Triazolam
Cannabinoids
11-Nor-9-carboxy-Δ9-THC
Cocaine
Benzoylecgonine
Cocaethylene
Cocaine
Norcocaine
Opiates/ Opioids
Acetylcodeine
Buprenorphine
Codeine
Dihydrocodeine
EDDP
Fentanyl
Hydrocodone
Hydromorphone
Meconin
Meperidine
Methadone
6-Monoacetylmorphine
Morphine
Naloxone
Naltrexone
Norbuprenorphine
Norcodeine
Norfentanyl
Normeperidine
Nortapentadol
Nortilidine
O-Desmethyltramadol
Oxycodone
Oxymorphone
Papaverine
Propoxyphene
Sufentanil
Tapentadol
Thebaine
Tilidine
Tramadol
Others
Ketamine
LSD
Mescaline
Norketamine
2-Oxo-3-hydroxy-LSD
PCP
Workflow Comparison
The new MassTox® Drugs of Abuse Testing assay offers significant optimizations in several areas and enables a considerably faster and more efficient workflow.
Chromatograms
The figure shows example chromatograms obtained with the MassTox® Drugs of Abuse assay.
Chromatogram of a MassCheck® Drugs of Abuse Testing control in negative ionization mode
Chromatogram of a MassCheck® Drugs of Abuse Testing control in positive ionization mode
Hydrolysis efficiency monitoring for every sample
The new, patented Chromsystems hydrolysis monitoring checks the efficiency of hydrolysis in every individual patient sample and also captures sample-specific effects. This allows samples with incomplete hydrolysis to be identified.
Functional Principle
An isotope-labeled hydrolysis marker (codeine-D6-glucuronide) is added to each sample. During incubation, this marker – like the other glucuronides in the sample – is cleaved (hydrolysed) by the hydrolysis enzyme.
A hydrolysis reference contains the same amount of hydrolysis marker but is processed without enzyme. As a result, the marker in it remains completely uncleaved.
Comparing the amount of uncleaved marker in
the sample and the reference allows the hydrolysis
efficiency to be determined. The less uncleaved
marker remains in the sample, the more efficient the
hydrolysis was.
Complete Hydrolysis in just 30 minutes
Provided no inhibitory effects occur, the optimised enzyme enables complete hydrolysis in just 30 minutes – even for analytes that are difficult to hydrolyse, such as codeine. This helps to ensure reliable and complete hydrolysis.
Coming soon: MassPrep® AddOn Drugs of Abuse Testing
An automated workflow for the MassTox® Drugs of Abuse Testing assay will soon be available on the MassPrep® system. The reagents and plates used are identical to those used in the manual MassTox® Drugs of Abuse Testing assay with 96 deep well plates.
- Schedule a personalised consultation tailored to your lab’s needs
- Place an order and discuss availability
- Learn how the MassTox® Drugs of Abuse Testing Assay can be integrated into your workflow
Don’t miss the opportunity to upgrade your Drugs of Abuse testing capabilities with a fully IVDR-compliant and efficient solution.
Brochure download
