Toggle Nav
Search
Login
My Cart
  • Compare Products
Menu

Parameter Set Neuroleptics 1/EXTENDED - LC-MS/MS

Order No.: 92912/XT/RUO
Parameters:
9-OH-Risperidone, Aripiprazole, Clozapine, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Olanzapine, Quetiapine, Risperidone

Encompasses 11 analytes
3PLUS1® Multilevel Calibrator Set available
Part of the modular system MassTox® Series A

 

main product photo

Aripiprazole

Dehydroaripiprazole

Clozapine

N-Desmethylclozapine

Haloperidol

Olanzapine

N-Desmethylolanzapine

Quetiapine

Norquetiapine

Risperidone

9-OH-Risperidone

Clinical relevance

This parameter set allows the quantitative determination of aripiprazole, dehydroaripiprazole, clozapine, N-desmethylclozapine, haloperidol, olanzapine, N-desmethylolanzapine, quetiapine, norquetiapine, risperidone and 9-OH-risperidone in human serum or plasma samples via liquid chromatography mass spectrometry (LC-MS/MS).

 

MassTox® Series A

The MassTox® Series A is a modular system that enables the determination of all analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® Basic Kit A
• Specific MassTox® Parameter Set
• Analytical column MassTox® TDM MasterColumn® A

More Information
Method of Analysis LC-MS/MS
Please note The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.
Specimen Serum/Plasma
Sample Preparation
  • Reconstitute the Internal Standard Mix.
  • Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent to form mixture A
  • Pipette 50 μl research sample/calibrator/MassCheck® control into a 1.5 ml reaction vial
  • Add 25 μl Extraction Buffer, mix briefly (vortex) and incubate 2 min.
  • Add 250 μl of mixture A and mix 30 s minimum (vortex) and centrifuge 5 min.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity
Run Time 3 min
Injection Volume 0.2 – 50 µl
Gradient

0.00 - 0.20 min    20 % Mobile Phase 2
0.21 - 0.70 min    50 % Mobile Phase 2
0.71 - 2.30 min    70 % Mobile Phase 2
2.31 - 3.00 min    20 % Mobile Phase 2
Ionisation ESI
MS/MS Mode MRM
Additional Info We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.
Parameters 9-OH-Risperidone, Aripiprazole, Clozapine, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Olanzapine, Quetiapine, Risperidone
The following components are included in the kit:
  1. 92028XT LCMS TDM Series A 3PLUS1 calibrator neuroleptics 1_XT
    3PLUS1® Multilevel Plasma Calibrator Set Neuroleptics 1/ EXTENDED
    Order no.: 92028/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  2. 0210XT 0211XT 0212XT TDM Series A contols neuroleptics1_XT
    MassCheck® Neuroleptics 1/EXTENDED Plasma Controls
    Order no.: 0210/XT; 0211/XT; 0212/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  3. Internal Standard Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED
    Internal Standard Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED
    Order no.: 92046/AN1/XT/RUO

    Component of the Parameter Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED, available separately

    Details
The following products are not included in the kit but are required for the application of the method:
  1. 92110 TDM Series A Master Column
    MassTox® TDM MasterColumn® A
    Order no.: 92110

    Analytical column for MassTox® Series A - LC-MS/MS

    Details
  2. Tuning Mix Neuroleptics 1/EXTENDED
    Tuning Mix Neuroleptics 1/EXTENDED
    Order no.: 92015/N1/XT/RUO

    Tuning Mix for Parameter Set Neuroleptics 1/EXTENDED

    Details
  3. Basic Kit A for 200 Tests - LC-MS/MS
    Basic Kit A for 200 Tests - LC-MS/MS
    Order no.: 92111/200/RUO

    Part of the modular system MassTox® Series A
    Provides all components required for sample prep and all mobile phases

    Details
  4. Basic Kit A for 1000 Tests - LC-MS/MS
    Basic Kit A for 1000 Tests - LC-MS/MS
    Order no.: 92111/1000/RUO

    Part of the modular system MassTox® Series A
    Provides all components required for sample prep and all mobile phases

    Details
  1. 92028XT LCMS TDM Series A 3PLUS1 calibrator neuroleptics 1_XT
    3PLUS1® Multilevel Plasma Calibrator Set Neuroleptics 1/ EXTENDED
    Order no.: 92028/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  1. 0210XT 0211XT 0212XT TDM Series A contols neuroleptics1_XT
    MassCheck® Neuroleptics 1/EXTENDED Plasma Controls
    Order no.: 0210/XT; 0211/XT; 0212/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  1. PEEK Prefilter Housing
    PEEK Prefilter Housing
    Order no.: 15010
    Details
  2. PEEK-encased Prefilter, 2 µm
    PEEK-encased Prefilter, 2 µm
    Order no.: 15011
    Details
  3. Reaction Vials, transparent, 1.5 ml
    Reaction Vials, transparent, 1.5 ml
    Order no.: 33006
    Details
  4. 15070 15071 Prefilter and Housing
    Stainless Steel Prefilter Housing
    Order no.: 15070
    Details
  5. Stainless Steel Prefilter - 0.5 µm
    Stainless Steel Prefilter - 0.5 µm
    Order no.: 15071
    Details

Aripiprazole

Dehydroaripiprazole

Clozapine

N-Desmethylclozapine

Haloperidol

Olanzapine

N-Desmethylolanzapine

Quetiapine

Norquetiapine

Risperidone

9-OH-Risperidone

Clinical relevance

This parameter set allows the quantitative determination of aripiprazole, dehydroaripiprazole, clozapine, N-desmethylclozapine, haloperidol, olanzapine, N-desmethylolanzapine, quetiapine, norquetiapine, risperidone and 9-OH-risperidone in human serum or plasma samples via liquid chromatography mass spectrometry (LC-MS/MS).

 

MassTox® Series A

The MassTox® Series A is a modular system that enables the determination of all analytes without changing column or mobile phases, thereby minimising the workload in the laboratory.
It consists of 3 parts:
• MassTox® Basic Kit A
• Specific MassTox® Parameter Set
• Analytical column MassTox® TDM MasterColumn® A

More Information
Method of Analysis LC-MS/MS
Please note The freely available information on this website, in particular on the sample preparation, are not sufficient to work with our products. Please read instructions and warning notices on products and/or instruction manuals.
Specimen Serum/Plasma
Sample Preparation
  • Reconstitute the Internal Standard Mix.
  • Add 800 μl Internal Standard Mix to 12 ml Precipitation Reagent to form mixture A
  • Pipette 50 μl research sample/calibrator/MassCheck® control into a 1.5 ml reaction vial
  • Add 25 μl Extraction Buffer, mix briefly (vortex) and incubate 2 min.
  • Add 250 μl of mixture A and mix 30 s minimum (vortex) and centrifuge 5 min.
  • Dilute the supernatant with Dilution Buffer prior to injection depending on the instrument sensitivity
Run Time 3 min
Injection Volume 0.2 – 50 µl
Gradient

0.00 - 0.20 min    20 % Mobile Phase 2
0.21 - 0.70 min    50 % Mobile Phase 2
0.71 - 2.30 min    70 % Mobile Phase 2
2.31 - 3.00 min    20 % Mobile Phase 2
Ionisation ESI
MS/MS Mode MRM
Additional Info We recommend to set the scan time to a value that allows to achieve a minimum of 10 data points over the whole peak width.
Parameters 9-OH-Risperidone, Aripiprazole, Clozapine, Haloperidol, N-Desmethylclozapine, N-Desmethylolanzapine, Olanzapine, Quetiapine, Risperidone
The following components are included in the kit:
  1. 92028XT LCMS TDM Series A 3PLUS1 calibrator neuroleptics 1_XT
    3PLUS1® Multilevel Plasma Calibrator Set Neuroleptics 1/ EXTENDED
    Order no.: 92028/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  2. 0210XT 0211XT 0212XT TDM Series A contols neuroleptics1_XT
    MassCheck® Neuroleptics 1/EXTENDED Plasma Controls
    Order no.: 0210/XT; 0211/XT; 0212/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  3. Internal Standard Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED
    Internal Standard Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED
    Order no.: 92046/AN1/XT/RUO

    Component of the Parameter Set Antidepressants 1/EXTENDED and Neuroleptics 1/EXTENDED, available separately

    Details
The following products are not included in the kit but are required for the application of the method:
  1. 92110 TDM Series A Master Column
    MassTox® TDM MasterColumn® A
    Order no.: 92110

    Analytical column for MassTox® Series A - LC-MS/MS

    Details
  2. Tuning Mix Neuroleptics 1/EXTENDED
    Tuning Mix Neuroleptics 1/EXTENDED
    Order no.: 92015/N1/XT/RUO

    Tuning Mix for Parameter Set Neuroleptics 1/EXTENDED

    Details
  3. Basic Kit A for 200 Tests - LC-MS/MS
    Basic Kit A for 200 Tests - LC-MS/MS
    Order no.: 92111/200/RUO

    Part of the modular system MassTox® Series A
    Provides all components required for sample prep and all mobile phases

    Details
  4. Basic Kit A for 1000 Tests - LC-MS/MS
    Basic Kit A for 1000 Tests - LC-MS/MS
    Order no.: 92111/1000/RUO

    Part of the modular system MassTox® Series A
    Provides all components required for sample prep and all mobile phases

    Details
  1. 92028XT LCMS TDM Series A 3PLUS1 calibrator neuroleptics 1_XT
    3PLUS1® Multilevel Plasma Calibrator Set Neuroleptics 1/ EXTENDED
    Order no.: 92028/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  1. 0210XT 0211XT 0212XT TDM Series A contols neuroleptics1_XT
    MassCheck® Neuroleptics 1/EXTENDED Plasma Controls
    Order no.: 0210/XT; 0211/XT; 0212/XT
    MassTox® Series A Neuroleptics 1/EXTENDED in Serum/Plasma – LC-MS/MS
    Details
  1. PEEK Prefilter Housing
    PEEK Prefilter Housing
    Order no.: 15010
    Details
  2. PEEK-encased Prefilter, 2 µm
    PEEK-encased Prefilter, 2 µm
    Order no.: 15011
    Details
  3. Reaction Vials, transparent, 1.5 ml
    Reaction Vials, transparent, 1.5 ml
    Order no.: 33006
    Details
  4. 15070 15071 Prefilter and Housing
    Stainless Steel Prefilter Housing
    Order no.: 15070
    Details
  5. Stainless Steel Prefilter - 0.5 µm
    Stainless Steel Prefilter - 0.5 µm
    Order no.: 15071
    Details