3PLUS1® Multilevel Plasma Calibrator Set Antiepileptic Drugs/EXTENDED

Order No.: 92025/XT
Parameters:
10,11-Dihydroxycarbamazepine, 10-OH-Carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic Acid, Vigabatrin, Zonisamide

Brivaracetam

Carbamazepine

Carbamazepine-10,11-epoxide

10,11-Dihydroxycarbamazepine

10-OH-Carbamazepine

Oxcarbamazepine

Ethosuximide

Felbamate

Gabapentin

Lacosamide

Lamotrigine

Levetiracetam (Keppra®)

N-Desmethylmesuximide

Perampanel

Phenobarbital

Phenylethylmalonamide (PEMA)

Phenytoin

Pregabalin

Primidone

Retigabine

Rufinamide

Stiripentol

Sultiame

Theophylline

Tiagabine

Topiramate

Valproic acid

Vigabatrin

Zonisamide

3PLUS1® Multilevel Plasma Calibrator Set Antiepileptic Drugs/EXTENDED, lyophilised
Related MassTox® Series A Parameter Set: Antiepileptic Drugs in Serum/Plasma (92921/RUO)

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method for the quantitative determination of antiepileptic drugs in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

More Information
Content 4 x 1 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

Substance

Calibrator 1

(mg/l)

Calibrator 2

(mg/l)

Calibrator 3

(mg/l)

Blank Calibrator

(mg/l)

10-OH-Carbamazepine

3.43

25.1

45.7

n.d. (<0.500)

Carbamazepine

1.62

8.35

14.0

n.d. (<0.371)

Carbamazepine-10.11-epoxide

0.158

5.64

10.3

n.d. (<0.021)

Carbamazepine-Diol

0.137

5.60

12.2

n.d. (<0.052)

Oxcarbazepine

0.137

1.83

3.60

n.d. (<0.020)

Felbamate

12.9

68.1

121

n.d. (<1.100)

Lacosamide

0.735

6.25

11.2

n.d. (<0.092)

Lamotrigine

1.51

9.66

17.0

n.d. (<0.192)

Levetiracetam

5.06

30.5

100.2

n.d. (<0.750)

Rufinamide

3.99

20.5

34.1

n.d. (<0.506)

Theophylline

6.22

15.7

24.7

n.d. (<1.01)

Gabapentin

1.58

14.5

25.5

n.d. (<0.315)

Pregabalin

0.146

6.35

12.2

n.d. (<0.025)

Sultiame

0.371

8.10

15.0

n.d. (<0.075)

Tiagabine (in µg/l)

13.5

126

230

n.d. (<2.00)

Topiramate

0.642

15.6

29.4

n.d. (<0.191)

Vigabatrin

1.48

22.7

41.2

n.d. (<0.297)

N-Desmethylmesuximide

6.99

27.5

47.3

n.d. (<1.42)

PEMA

0.997

6.31

11.2

n.d. (<0.149)

Phenytoin

3.45

13.9

23.4

n.d. (<0.715)

Primidone

3.06

11.4

18.7

n.d. (<0.502)

Stiripentol

2.80

14.4

24.1

n.d. (<0.413)

Ethosuximide

20.3

66.4

110

n.d. (<6.11)

Phenobarbital

6.34

30.8

55.1

n.d. (<0.925)

Valproic acid

28.4

73.4

120

n.d. (<8.83)

Zonisamide

3.73

27.6

49.1

n.d. (<1.43)

Brivaracetam

0.618

2.42

4.19

n.d. (<0.074)

Perampanel (in µg/l)

35.7

1003

1780

n.d. (<20.0)

Retigabine (in µg/l)

48.7

1058

2050

n.d. (<28.0)

n.d. = not determined, analytes under LOQ

The blank level is manufactured using the same matrix pool as used for the calibrator levels 1, 2 and 3. It was not fortified with any antiepileptic drugs.

Storage conditions Stored below –18 °C unopened calibration standards are stable until the expiry date which is stated on the vial labels. The reconstituted calibration standards when kept light protected, well closed and cool (+2 to +8 °C) are stable for 2 days. If the calibrators cannot be analysed within this period, they should be aliquoted and stored frozen below -18 °C (up to 3 months).
Method of Analysis LC-MS/MS
Parameter 10,11-Dihydroxycarbamazepine, 10-OH-Carbamazepine, Brivaracetam, Carbamazepine, Carbamazepine-10,11-epoxide, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam (Keppra®), N-Desmethylmesuximide, Oxcarbamazepine, Perampanel, Phenobarbital, Phenylethylmalonamide (PEMA), Phenytoin, Pregabalin, Primidone, Retigabine, Rufinamide, Stiripentol, Sultiame, Theophylline, Tiagabine, Topiramate, Valproic Acid, Vigabatrin, Zonisamide
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