Vitamin B12/MMA
| Title | Summary | Year |
| Vitamin B12 deficiency prevalence and associated biomarkers in type 2 Diabetes (T2DM) treated with metformin: biochemical assessment in a series of 106 patients | The 2018 ADA Clinical Practice Recommendations endorse screening Metformin users for vitamin B12 deficiency. In our series, diabetic patients treated by metformin had B12 deficiency in 17% of cases (total B12) and only in 8.5% (HTC). MMA measured with Chromsystems assay. | 2019 |
| Title | Summary | Year |
| Poster: A rapid and simple LC-MS/MS diagnostic test for the exclusion of methylmalonic acidemia | The LC-MS/MS method presented here for the analysis of MMA in urine is suitable for identifying methylmalonic acidemia and, with regard to quality, is comparable with the GC-MS reference method. Here, the sample preparation consists only of the addition of an internal standard to the urine sample and a dilution step. | 2015 |
| Poster: Quantitative target metabolomics using LC-MS/MS improves the diagnosis of vitamin B12 deficiency & saves cost and time | Vitamin B12 deficiency in screening studies can be detected using modern metabolites adapted to LC-MS/MS instrumentation. Using this approach by routine laboratories improves early diagnosis of vitamin B12 and therapy monitoring, hence reducing irreversible complications. The LCMS/MS method shown is characterised by fast sample preparation, minimal matrix effects, high precision, robustness and cost-effectiveness. | 2014 |
| Poster: A novel mass spectrometry kit for MMA in plasma/serum and urine | This novel assay for the determination of MMA from plasma/serum and urine using LC-MS/MS is comparable with the GC-MS reference method in accuracy. The method is characterised by fast sample preparation, minimal matrix effects, high precision, robustness and cost-effectiveness. | 2014 |
Please find here publications as guides for reference ranges or therapeutic ranges. They may differ from other published data and are only intended to serve as a rough guide. As data vary depending on patient population and measurement method, please determine ranges for your laboratory. When determining ranges make sure that you comply with local national requirements.
| Title | Summary | Year |
| Thomas L. (ed)- Labor und Diagnose, 8th edition, TH books (2012) | Book with reference ranges. | 2012 |
| The Clinical Evaluation of Cobalamin Deficiency by Determination of Methylmalonic Acid in Serum or Urine Is Not Invalidated by the Presence of Heterozygous Methylmalonic-Acidaemia | Paper discusses the usefulness of measurement of methylmalonic acid in serum or urine for the clinical evaluation of cobalamin deficiency and the reference values. | 1990 |