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3PLUS1® Multilevel Plasma Calibrator Set Antiarrhythmic Drugs

Order No.: 92052
Parameters:
Acebutolol, Ajmaline, Amiodarone, Aprindine, Atenolol, Bisoprolol, Debutyldronedarone, Desethylamiodarone, Diltiazem, Disopyramide, Dronedarone, Flecainide, Flunarizine, Gallopamil, Hydroquinidine, Lidocaine, Metoprolol, Mexiletine, Norverapamil, Propafenone, Propranolol, Quinidine, Sotalol, Tocainide, Verapamil
main product photo

Acebutolol

Ajmaline

Amiodarone

Desethylamiodarone

Aprindine

Atenolol

Bisoprolol

Diltiazem

Disopyramide

Dronedarone

Debutyldronedarone

Flecainide

Flunarizine

Gallopamil

Lidocaine

Metoprolol

Mexiletine

Propafenone

Propranolol

Quinidine

Hydroquinidine

Sotalol

Tocainide

Verapamil

Norverapamil

3PLUS1® Multilevel Plasma Calibrator Set Antiarrhythmic Drugs, lyophilised

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method for the quantitative determination of antiarrhythmic drugs in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

More Information
Content 4 x 1 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

NEW: An Excel file with the data from the product information leaflet is now available in the "Downloads" section (for registered customers only). This eliminates manual data entry of large data sets.

Substance Calibrator 1
(µg/l)		Calibrator 2
(µg/l)		Calibrator 3
(µg/l)		Blank Calibrator
(µg/l)
Group 1        
Atenolol 77.6 1351 2619 n.d. (< 10.0)
Sotalol 331 2950 5536 n.d. (< 80.0)
Group 2        
Acebutolol 141 1241 2346 n.d. (< 4.0)
Ajmaline 6.82 582 1175 n.d. (< 5.0)
Quinidine 191 3428 6736 n.d. (< 25.0)
Hydroquinidine 180 5925 10925 n.d. (< 25.0)
Disopyramide 14393 5291 9281 n.d. (< 45.0)
Metoprolol 14.6 362 709 n.d. (< 5.0)
Lidocaine 652 3522 6332 n.d. (< 40.0)
Tocainide 705 6898 12489 n.d. (< 40.0)
Group 3        
Bisoprolol 6.7 57.3 109 n.d. (< 4.0)
Diltiazem 20.5 229 447 n.d. (< 2.0)
Flecainide 133 749 1495 n.d. (< 2.5)
Mexiletine 67.9 1194 2294 n.d. (< 17.5)
Propranolol 14.3 189 356 n.d. (< 8.0) 
Verapamil 34.1 423 830 n.d. (< 4.0) 
Norverapamil 41.2 284 497 n.d. (< 5.0) 
Gallopamil 13.8 66.4 116 n.d. (< 2.0) 
Group 4        
Amiodarone 377 1712 3071 n.d. (< 45.0)
Desethylamiodarone 408 2218 4097 n.d. (< 10.0)
Aprindine 501 1671 2797 n.d. (< 16.0)
Dronedarone 30.1 121 220 n.d. (< 2.0)
Debutyldronedarone 28.2 110 196 n.d. (< 4.0)
Flunarizine 17.3 118 218 n.d. (< 1.5)
Propafenone 32.0 1525 2937 n.d. (< 10.0)

n.d. = not detected (< LOQ)
The blank level is manufactured using the same matrix pool as used for the calibrator levels 1-3. It was not fortified with any antiarrhythmic drugs.
Method of Analysis LC-MS/MS
Parameters Acebutolol, Ajmaline, Amiodarone, Aprindine, Atenolol, Bisoprolol, Debutyldronedarone, Desethylamiodarone, Diltiazem, Disopyramide, Dronedarone, Flecainide, Flunarizine, Gallopamil, Hydroquinidine, Lidocaine, Metoprolol, Mexiletine, Norverapamil, Propafenone, Propranolol, Quinidine, Sotalol, Tocainide, Verapamil
As a customer please login or register to gain full access.

Acebutolol

Ajmaline

Amiodarone

Desethylamiodarone

Aprindine

Atenolol

Bisoprolol

Diltiazem

Disopyramide

Dronedarone

Debutyldronedarone

Flecainide

Flunarizine

Gallopamil

Lidocaine

Metoprolol

Mexiletine

Propafenone

Propranolol

Quinidine

Hydroquinidine

Sotalol

Tocainide

Verapamil

Norverapamil

3PLUS1® Multilevel Plasma Calibrator Set Antiarrhythmic Drugs, lyophilised

These lyophilised calibrators from Chromsystems are based on human plasma and should be used according to the instruction manual. They are designed to calibrate the measurement method for the quantitative determination of antiarrhythmic drugs in serum/plasma. While following the instructions the calibrators should be handled and measured in the same manner as a patient specimen.
These calibrators are only available as multilevel calibrator set with 3 different concentration levels plus 1 blank value.

More Information
Content 4 x 1 ml (lyoph.)
Concentrations

Please note: Concentration values shown here are typical. For lot specific concentration values please refer to the product insert supplied with the materials. The product inserts can also be requested from us directly or downloaded from our website after login.

NEW: An Excel file with the data from the product information leaflet is now available in the "Downloads" section (for registered customers only). This eliminates manual data entry of large data sets.

Substance Calibrator 1
(µg/l)		Calibrator 2
(µg/l)		Calibrator 3
(µg/l)		Blank Calibrator
(µg/l)
Group 1        
Atenolol 77.6 1351 2619 n.d. (< 10.0)
Sotalol 331 2950 5536 n.d. (< 80.0)
Group 2        
Acebutolol 141 1241 2346 n.d. (< 4.0)
Ajmaline 6.82 582 1175 n.d. (< 5.0)
Quinidine 191 3428 6736 n.d. (< 25.0)
Hydroquinidine 180 5925 10925 n.d. (< 25.0)
Disopyramide 14393 5291 9281 n.d. (< 45.0)
Metoprolol 14.6 362 709 n.d. (< 5.0)
Lidocaine 652 3522 6332 n.d. (< 40.0)
Tocainide 705 6898 12489 n.d. (< 40.0)
Group 3        
Bisoprolol 6.7 57.3 109 n.d. (< 4.0)
Diltiazem 20.5 229 447 n.d. (< 2.0)
Flecainide 133 749 1495 n.d. (< 2.5)
Mexiletine 67.9 1194 2294 n.d. (< 17.5)
Propranolol 14.3 189 356 n.d. (< 8.0) 
Verapamil 34.1 423 830 n.d. (< 4.0) 
Norverapamil 41.2 284 497 n.d. (< 5.0) 
Gallopamil 13.8 66.4 116 n.d. (< 2.0) 
Group 4        
Amiodarone 377 1712 3071 n.d. (< 45.0)
Desethylamiodarone 408 2218 4097 n.d. (< 10.0)
Aprindine 501 1671 2797 n.d. (< 16.0)
Dronedarone 30.1 121 220 n.d. (< 2.0)
Debutyldronedarone 28.2 110 196 n.d. (< 4.0)
Flunarizine 17.3 118 218 n.d. (< 1.5)
Propafenone 32.0 1525 2937 n.d. (< 10.0)

n.d. = not detected (< LOQ)
The blank level is manufactured using the same matrix pool as used for the calibrator levels 1-3. It was not fortified with any antiarrhythmic drugs.
Method of Analysis LC-MS/MS
Parameters Acebutolol, Ajmaline, Amiodarone, Aprindine, Atenolol, Bisoprolol, Debutyldronedarone, Desethylamiodarone, Diltiazem, Disopyramide, Dronedarone, Flecainide, Flunarizine, Gallopamil, Hydroquinidine, Lidocaine, Metoprolol, Mexiletine, Norverapamil, Propafenone, Propranolol, Quinidine, Sotalol, Tocainide, Verapamil
As a customer please login or register to gain full access.