Easy Access to Clinical LC-MS/MS

For more than 30 years, Chromsystems is one of the world's leading manufacturers of routine clinical diagnostics solutions for LC-MS/MS and HPLC. We are providing clinical laboratories with IVD-compliant reliable products and contribute to safe and cost-efficient diagnostics.

Our solutions enable any laboratory to introduce mass spectrometry into the diagnostic routine.


Complete and Fully Validated Assays


Studies: Comparisons LC-MS/MS vs. Traditional Methods

Chromatogram of the Chromsystems-assay – more than 100 drugs can be tested within a single run

LC-MS/MS vs GC-MS in Drugs of Abuse Testing

The most common screening method for drugs of abuse, immunoassays, has its limitations: results are often class-specific and cannot be attributed to a specific drug or drug metabolite. An immunoassay requires a second analytical procedure to confirm the quantitative determination, and this is usually performed by either GC-MS or LC-MS. LC-MS/MS has an accuracy and selectivity that is sufficient to do both in one step. This is why commercial assays, such as those from Chromsystems, enable the target screening and quantitative confirmation of more than 100 drugs in a single run.

A laboratory tested a commercial LC-MS/MS assay (MassTox® Drugs of Abuse Testing, Chromsystems) and compared it with GC-MS, with a focus on routine analysis. The lab also conducted a comparative analysis between the commercial assay and an in-house LC-MS assay used by an external accredited laboratory.  


LC-MS/MS vs IEC in Amino Acid Analysis (AAA)

The quantitative amino acid analysis (AAA) is crucial for the diagnosis of inherited diseases, e. g. phenylketonuria (PKU) and maple syrup urine disease (MSUD). Over the years, the gold standard technique has been ion exchange chromatography (IEC), but some of the practical disadvantages of IEC are a poor retention of acidic compounds, single point calibrations, and the need for post-experimental analysis programmes. Its operation has been unchanged for over four decades. However, one major roadblock for clinical laboratories is a long analysis time of more than 120 minutes.

A new study by Carling et al looked at LC-MS/MS as an alternative method. The researchers compared IEC with different commercial LC-MS/MS assays for the determination in human plasma samples, including the MassChrom® Amino Acid Analysis test. Generally, not all LC-MS/MS methods showed the performance required for all analytes.

However, the analysis carried out with the Chromsystems MassChrom® assay showed a performance comparable to IEC, but with a higher degree of specificity and a much quicker analysis time of less than 19 minutes for 48 amino acids.

The Chromsystems-assay provides an efficient separation of all isobars such as Leu, Ile and Allo-Ile


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Comparison: LC-MS/MS in Drugs of Abuse Testing

The most common screening method for drugs of abuse, immunoassays, has its limitations: results are often class-specific and cannot be attributed to a specific drug or drug metabolite. An immunoassay requires a second analytical procedure to confirm the quantitative determination, and this is usually performed by either GC-MS or LC-MS. LC-MS/MS has an accuracy and selectivity that is a sufficient to do both in one step. This is why commercial assays, such as those from Chromsystems, enable the target screening and quantitative confirmation of more than 100 drugs in a single run.

Comparison: LC-MS/MS in Amino Acid Analysis (AAA)

The quantitative amino acid analysis (AAA) is crucial for the diagnosis of inherited diseases, e. g. phenylketonuria (PKU) and maple syrup urine disease (MSUD). Over the years, the gold standard technique has been ion exchange chromatography (IEC), but some of the practical disadvantages of IEC are a poor retention of acidic compounds, single point calibrations, and the need for post-experimental analysis programmes. Its operation has been unchanged for over four decades. However, one major roadblock for clinical laboratories is a long analysis time of more than 120 minutes.

A laboratory tested a commercial LC-MS/MS assay (MassTox® Drugs of Abuse Testing, Chromsystems) and compared it with GC-MS, with a focus on routine analysis. The lab also conducted comparative analysis between the commercial assay and an in-house LC-MS assay used by an external accredited laboratory.  

Chromatogram of the commercial assay – more than 100 drugs can be tested within a single run

A new study by Carling et al looked at LC-MS/MS as an alternative method. The researchers compared IEC with different commercial LC-MS/MS assays for the determination in human plasma samples, including the MassChrom® Amino Acid Analysis test. Generally, not all LC-MS/MS methods showed the performance required for all analytes.

However, the analysis carried out with the Chromsystems MassChrom® assay showed a performance comparable to IEC, but with a higher degree of specificity and a much quicker analysis time of less than 19 minutes for 48 amino acids.

The Chromsystems-assay provides an efficient separation of all isobars such as Leu, Ile and Allo-Ile